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http://hdl.handle.net/2445/167783
Title: | The EMT signaling pathways in endometrial carcinoma |
Author: | Colás, Eva Pedrola, Nuria Devis, Laura Ertekin, Tugçe Campoy, Irene Martínez Sáez, Elena Llauradó, Marta Rigau, Marina Olivan Riera, Mireia Garcia, Marta Cabrera, Sílvia Gil Moreno, Antonio Xercavins, Jordi Castellví, Josep Garcia, Angel Ramón y Cajal Agüeras, Santiago Moreno-Bueno, Gema Dolcet, Xavier Alameda, Francesc Palacios, José Prat, Jaime Doll, Andreas Matias-Guiu, Xavier Abal Posada, Miguel Reventós Puigjaner, Jaume |
Keywords: | Càncer d'endometri Càncer Epiteli Genètica Endometrial cancer Cancer Epithelium Genetics |
Issue Date: | 1-Oct-2012 |
Publisher: | Springer Verlag |
Abstract: | Endometrial cancer (EC) is the most common gynecologic malignancy of the female genital tract and the fourth most common neoplasia in women. In EC, myometrial invasion is considered one of the most important prognostic factors. For this process to occur, epithelial tumor cells need to undergo an epithelial to mesenchymal transition (EMT), either transiently or stably, and to differing degrees. This process has been extensively described in other types of cancer but has been poorly studied in EC. In this review, several features of EMT and the main molecular pathways responsible for triggering this process are investigated in relation to EC. The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation. Pathways including progesterone receptor, TGFβ, ETV5 and microRNAs are deeply related to the EMT process in EC. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/s12094-012-0866-3 |
It is part of: | Clinical & Translational Oncology, 2012, vol. 14, num. 10, p. 715-720 |
URI: | http://hdl.handle.net/2445/167783 |
Related resource: | https://doi.org/10.1007/s12094-012-0866-3 |
ISSN: | 1699-048X |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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