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Title: The EMT signaling pathways in endometrial carcinoma
Author: Colás, Eva
Pedrola, Nuria
Devis, Laura
Ertekin, Tugçe
Campoy, Irene
Martínez Sáez, Elena
Llauradó, Marta
Rigau, Marina
Olivan Riera, Mireia
Garcia, Marta
Cabrera, Sílvia
Gil Moreno, Antonio
Xercavins, Jordi
Castellví, Josep
Garcia, Angel
Ramón y Cajal Agüeras, Santiago
Moreno-Bueno, Gema
Dolcet, Xavier
Alameda, Francesc
Palacios, José
Prat, Jaime
Doll, Andreas
Matias-Guiu, Xavier
Abal Posada, Miguel
Reventós Puigjaner, Jaume
Keywords: Càncer d'endometri
Endometrial cancer
Issue Date: 1-Oct-2012
Publisher: Springer Verlag
Abstract: Endometrial cancer (EC) is the most common gynecologic malignancy of the female genital tract and the fourth most common neoplasia in women. In EC, myometrial invasion is considered one of the most important prognostic factors. For this process to occur, epithelial tumor cells need to undergo an epithelial to mesenchymal transition (EMT), either transiently or stably, and to differing degrees. This process has been extensively described in other types of cancer but has been poorly studied in EC. In this review, several features of EMT and the main molecular pathways responsible for triggering this process are investigated in relation to EC. The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation. Pathways including progesterone receptor, TGFβ, ETV5 and microRNAs are deeply related to the EMT process in EC.
Note: Versió postprint del document publicat a:
It is part of: Clinical & Translational Oncology, 2012, vol. 14, num. 10, p. 715-720
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ISSN: 1699-048X
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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