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http://hdl.handle.net/2445/167962
Title: | Low-dose statin treatment increases prostate cancer aggressiveness |
Author: | Caro Maldonado, Alfredo Camacho, Laura Zabala Letona, Amaia Torrano, Verónica Fernández Ruiz, Sonia Zamacola-Bascaran, Kepa Arreal, Leire Valcárcel-Jiménez, Lorea Martín-Martín, Natalia Flores, Juana María Cortazar, Ana Rosa Zúñiga García, Patricia Arruabarrena-Aristorena, Amaia Guillaumond, Fabienne Cabrera, Diana Falcón Pérez, Juan M. Aransay, Ana M. Gomez-Muñoz, Antonio Olivan Riera, Mireia Morote, Juan Carracedo, Arkaitz |
Keywords: | Colesterol Obesitat Càncer de pròstata Cholesterol Obesity Prostate cancer |
Issue Date: | 5-Jan-2018 |
Publisher: | Impact Journals |
Abstract: | Prostate cancer is diagnosed late in life, when co-morbidities are frequent. Among them, hypertension, hypercholesterolemia, diabetes or metabolic syndrome exhibit an elevated incidence. In turn, prostate cancer patients frequently undergo chronic pharmacological treatments that could alter disease initiation, progression and therapy response. Here we show that treatment with anti-cholesterolemic drugs, statins, at doses achieved in patients, enhance the pro-tumorigenic activity of obesogenic diets. In addition, the use of a mouse model of prostate cancer and human prostate cancer xenografts revealed that in vivo simvastatin administration alone increases prostate cancer aggressiveness. In vitro cell line systems supported the notion that this phenomenon occurs, at least in part, through the direct action on cancer cells of low doses of statins, in range of what is observed in human plasma. In sum, our results reveal a prostate cancer experimental system where statins exhibit an undesirable effect, and warrant further research to address the relevance and implications of this observation in human prostate cancer. |
Note: | Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.22217 |
It is part of: | Oncotarget, 2018, vol. 9, num. 2, p. 1494-1504 |
URI: | http://hdl.handle.net/2445/167962 |
Related resource: | https://doi.org/10.18632/oncotarget.22217 |
ISSN: | 1949-2553 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Publicacions de projectes de recerca finançats per la UE |
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