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Title: HPV vaccination: Are we overlooking additional opportunities to control HPV infection and transmission?
Author: Vorsters, Alex
Van Damme, Pierre
Bosch Aparici, Francisco Javier
Keywords: Vacuna del papil·lomavirus
Malalties infeccioses
Papillomavirus vaccines
Communicable diseases
Issue Date: 1-Nov-2019
Publisher: Elsevier Sci Ltd
Abstract: Human papillomavirus virus-like particles (HPV VLPs) have distinctive immunogenic properties that generate a durable antibody response, producing high-quality neutralizing antibodies. By vaccination, i.e., intramuscular injection of these HPV VLPs, the viral survival strategy of avoiding exposure to the systemic immune system is completely overruled, and large amounts of vaccine-induced systemic antibodies are generated. These systemic circulating antibodies are easily transuded to the genital mucosa and are detectable in female genital secretions. It is well accepted that these antibodies interact with the virions presented by an infected partner and inhibit infection. However, much less attention has been paid to the role of anti-HPV vaccine-induced antibodies in an HPV-infected individual where infectious virions are encountered by neutralizing antibodies in mucosal secretions. There is a clear need to further investigate and document this role. Indeed, if HPV vaccination of HPV-infected women has an effect on HPV transmission, auto-inoculation, and relapse after treatment, this may influence how we model, assess, and implement HPV vaccination programmes. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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It is part of: International Journal Of Infectious Diseases, 2019-11-01, Vol. 88, P. 110-112
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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