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DC Field | Value | Language |
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dc.contributor.author | Kelly, Hellen | - |
dc.contributor.author | Benavente, Yolanda | - |
dc.contributor.author | Pavon, Miquel Angel | - |
dc.contributor.author | Sanjosé Llongueras, Silvia de | - |
dc.contributor.author | Mayaud, Philippe | - |
dc.contributor.author | Lorincz, Attila Tibor | - |
dc.date.accessioned | 2020-07-07T15:32:24Z | - |
dc.date.available | 2020-07-07T15:32:24Z | - |
dc.date.issued | 2019-11-26 | - |
dc.identifier.uri | http://hdl.handle.net/2445/168040 | - |
dc.description.abstract | BACKGROUND: To conduct a meta-analysis of performance of DNA methylation in women with high-grade cervical intraepithelial neoplasia (CIN2+). METHODS: Medline and Embase databases were searched for studies of methylation markers versus histological endpoints. Pooled sensitivity, specificity and positive predictive value (PPV) for CIN2+ were derived from bivariate models. Relative sensitivity and specificity for CIN2+ compared to cytology and HPV16/18 genotyping were pooled using random-effects models. RESULTS: Sixteen thousand three hundred thirty-six women in 43 studies provided data on human genes (CADM1, MAL, MIR-124-2, FAM19A4, POU4F3, EPB41L3, PAX1, SOX1) and HPV16 (L1/L2). Most (81%) studies evaluated methylation assays following a high-risk (HR)-HPV-positive or abnormal cytology result. Pooled CIN2+ and CIN3+ prevalence was 36.7% and 21.5%. For a set specificity of 70%, methylation sensitivity for CIN2+ and CIN3+ were 68.6% (95% CI: 62.9-73.8) and 71.1% (95% CI: 65.7-76.0) and PPV were 53.4% (95% CI: 44.4-62.1) and 35.0% (95% CI: 28.9-41.6). Among HR-HPV+ women, the relative sensitivity of methylation for CIN2+ was 0.81 (95% CI: 0.63-1.04) and 1.22 (95% CI: 1.05-1.42) compared to cytology of atypical squamous cells of undetermined significance, or greater (ASCUS+) and HPV16/18 genotyping, respectively, while relative specificity was 1.25 (95% CI: 0.99-1.59) and 1.03 (95% CI: 0.94-1.13), respectively. CONCLUSION: DNA methylation is significantly higher in CIN2+ and CIN3+ compared to <= CIN1. As triage test, DNA methylation has higher specificity than cytology ASCUS+ and higher sensitivity than HPV16/18 genotyping. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41416-019-0593-4 | - |
dc.relation.ispartof | British Journal Of Cancer, 2019-11-26, vol. 121, num. 11, p. 954-965 | - |
dc.relation.uri | https://doi.org/10.1038/s41416-019-0593-4 | - |
dc.rights | cc by (c) Kelly, Hellen et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de coll uterí | - |
dc.subject.classification | Marcadors tumorals | - |
dc.subject.other | Cervix cancer | - |
dc.subject.other | Tumor markers | - |
dc.title | Performance of DNA methylation assays for detection of high-grade cervical intraepithelial neoplasia (CIN2+): a systematic review and meta-analysis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-07-06T08:26:58Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/796581/EU//MEsHH | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31616037 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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