Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/168103
Title: | Theophylline is able to partially revert cachexia in tumour-bearing rats |
Author: | Olivan Riera, Mireia Springer, Jochen Busquets Rius, Sílvia Tschirner, Anika Figueras, Maite Toledo Soler, Miriam Fontes de Oliveira, Cibely Cristine Genovese, Maria Inês Ventura da Silva, Paula Sette, Angelica López-Soriano, Francisco J. Anker, Stefan Argilés Huguet, Josep Ma. |
Keywords: | Teofil·lina Caquèxia Ratolins (Animals de laboratori) Theophylline Cachexia Mice (Laboratory animals) |
Issue Date: | 21-Aug-2012 |
Publisher: | BioMed Central |
Abstract: | Background and aims: the aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia. Methods: the in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment. Results: Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function. Conclusion: Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/1743-7075-9-76 |
It is part of: | Nutrition and Metabolism, 2012, vol. 9, num. 1, p. 76 |
URI: | http://hdl.handle.net/2445/168103 |
Related resource: | https://doi.org/10.1186/1743-7075-9-76 |
ISSN: | 1743-7075 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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