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dc.contributor.authorChukwu, J.U.-
dc.contributor.authorLópez Martínez, Ma. Concepción-
dc.contributor.authorGonzález Gazulla, Asensio-
dc.contributor.authorFont Bardia, Ma. Mercedes-
dc.contributor.authorCalvet Pallàs, Maria Teresa-
dc.contributor.authorMesseguer i Peypoch, Ramon-
dc.contributor.authorCalvis, Carme-
dc.description.abstractThe study of the reactivity of the novel pyrazole derivative [1-{MeOe(CH2)2e}-3,5-Ph2e(C3HN2)] (1) with Na2[PdCl4] or Pd(OAc)2 under different experimental conditions has allowed us to isolate and characterize the trans-isomers of [Pd{[1-{MeOe(CH2)2e}-3,5-Ph2e(C3HN2)]}2(X)2] [X ¼ Cl (2) or OAc (3)] and the di-m-ligand bridged cyclopalladated complexes [Pd{k2,C,N[1-{MeOe(CH2)2e}-3-(C6H4),5-Ph- (C3HN2)]}(m-X)]2 [X ¼ OAc (4) or Cl (5)]. Further treatment of compounds 4 or 5 with PPh3 in CH2Cl2 produced the bridge splitting and the formation of [Pd{k2,C,N[1-{MeOe(CH2)2e}-3-(C6H4),5-Ph- (C3HN2)]}X(PPh3)] [X ¼ OAc (6) or Cl (7)]. The cytotoxic assessment of the free ligand (1) and the Pd(II) complexes on the two breast cancer cell lines MCF7 and MDA-MB231 reveals that: a) compound 1 is less active than its analogue [1-{Me2Ne(CH2)2e}-3,5-Ph2e(C3HN2)] (Ic) and b) palladacycles 4e7 showed a remarkable cytotoxic activity in the MDA-MB231 cell line (with IC50 values in the range 9.1e14.4 mM).-
dc.format.extent26 p.-
dc.publisherElsevier B.V.-
dc.relation.isformatofVersió postprint del document publicat a:
dc.relation.ispartofJournal of Organometallic Chemistry, 2014, vol. 766, p. 13-21-
dc.rights(c) Elsevier B.V., 2014-
dc.subject.classificationEstructura cristal·lina (Sòlids)-
dc.subject.classificationQuímica organometàl·lica-
dc.subject.classificationPal·ladi (Element químic)-
dc.subject.otherLayer structure (Solids)-
dc.subject.otherOrganometallic chemistry-
dc.titlePd(II) complexes with N-substituted pyrazoles as ligands. The influence of the R group [OMe versus NMe2] of [1-{R(CH2)2}-3,5-Ph2(C3HN2)] on their cytotoxic activity on breast cancer cell lines-
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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