Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/168599
Title: | HERC ubiquitin ligases in cancer |
Author: | Sala Gaston, Joan Martinez-Martinez, Arturo Pedrazza, Leonardo Lorenzo-Martín, L. Francisco Caloto, Rubén Bustelo, Xosé R. Ventura Pujol, Francesc Rosa López, José Luis |
Keywords: | Genomes Oncogens Proteïnes supressores de tumors Genomes Oncogenes Tumor suppressor protein |
Issue Date: | 22-Jun-2020 |
Publisher: | MDPI |
Abstract: | HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3-HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell proliferation, cell migration, and immune responses. Accumulating evidence also shows that this family plays critical roles in cancer. In this review, we provide an integrated view of the role of these ligases in cancer, highlighting their bivalent functions as either oncogenes or tumor suppressors, depending on the tumor type. We include a discussion of both the molecular mechanisms involved and the potential therapeutic strategies. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers12061653 |
It is part of: | Cancers, 2020, vol. 12, num. 6, p. E1653 |
URI: | http://hdl.handle.net/2445/168599 |
Related resource: | https://doi.org/10.3390/cancers12061653 |
ISSN: | 2072-6694 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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