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Title: Prevention of Rotavirus Diarrhea in Suckling Rats by a Specific Fermented Milk Concentrate with Prebiotic Mixture
Author: Rigo Adrover, Maria del Mar
Knipping, K.
Garssen, J.
van Limpt, Kees
Knol, J.
Franch i Masferrer, Àngels
Castell, Margarida
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
Keywords: Diarrea
Malalties inflamatòries intestinals
Inflammatory bowel diseases
Issue Date: 1-Jan-2019
Publisher: MDPI
Abstract: Several microbial modulatory concepts, such as certain probiotics and prebiotics, confer protection against gastrointestinal infections, among which is acute diarrhea caused by the rotavirus (RV). Other microbiota modulators, such as postbiotics, produced during fermentation, might also have the potential to counteract RV infection. In light of this, a fermented milk, made by using Bifidobacterium breve C50 (BbC50) and Streptococcus thermophilus 065 (St065) with a prebiotic mixture¿short chain galactooligosaccharides/long chain fructooligosaccharides (scGOS/lcFOS 9:1)¿with potential to impact the intestinal microbiota composition was tested. An RV infected rat model was used to evaluate the amelioration of the infectious process and the improvement of the immune response induced by the fermented milk with prebiotic mixture. The dietary intervention caused a reduction in the clinical symptoms of diarrhea, such as severity and incidence. Furthermore, a modulation of the immune response was observed, which might enhance the reduction of the associated diarrhea. In addition, the fermented milk with prebiotic mixture was able to bind the virus and reduce its clearance. In conclusion, the postbiotic components in the fermented milk in combination with the prebiotics used here showed protective properties against RV infection.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2019, vol. 11, num. 1
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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