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Title: Human secretory IgM emerges from plasma cells clonally related to gut memory B cells and targets highly diverse commensals
Author: Magri, Giuliana
Comerma, Laura
Pybus, Marc
Sintes, Jordi
Lligé, David
Segura-Garzón, Daniel
Bascones, Sabrina
Yeste, Ada
Grasset, Emilie K.
Gutzeit, Cindy
Uzzan, Mathieu
Ramanujam, Meera
van Zelm, Menno C.
Albero González, Raquel
Vazquez, Ivonne
Iglesias, Mar
Serrano, Sergi
Márquez, Lucía
Mercadé Gil, M. Elena
Mehandru, Saurabh
Cerutti, Andrea
Keywords: Cèl·lules B
Mucosa gastrointestinal
B cells
Gastrointestinal mucosa
Issue Date: Jul-2017
Publisher: Cell Press
Abstract: Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM+ plasma cells (PCs) were more abundant in humans than mice and clonally related to a large repertoire of memory IgM+ B cells disseminated throughout the intestine but rare in systemic lymphoid organs. In addition to sharing a gut-specific gene signature with memory IgA+ B cells, memory IgM+ B cells were related to some IgA+ clonotypes and switched to IgA in response to T cell-independent or T cell-dependent signals. These signals induced abundant IgM which, together with SIgM from clonally affiliated PCs, recognized mucus-embedded commensals. Bacteria recognized by human SIgM were dually coated by SIgA and showed increased richness and diversity compared to IgA-only-coated or uncoated bacteria. Thus, SIgM may emerge from pre-existing memory rather than newly activated naive IgM+ B cells and could help SIgA to anchor highly diverse commensal communities to mucus.
Note: Versió postprint del document publicat a:
It is part of: Immunity, 2017, vol. 47, num. 1, p. 118-134
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ISSN: 1074-7613
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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