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http://hdl.handle.net/2445/169354
Title: | Biological properties of extracellular vesicles and their physiological functions |
Author: | Yáñez-Mó, María Siljander, Pia R.M. Andreu, Zoraida Bedina Zavec, Apolonija Borràs, Francesc E. Buzas, Edit I. Buzas, Krisztina Casal, Enriqueta Cappello, Francesco Carvalho, Joana Colás, Eva Cordeiro-da-Silva, Anabela Fais, Stefano Falcon Perez, Juan Manuel Ghobrial, Irene M. Giebel, Bernd Gimona, Mario Graner, Michael Gursel, Ihsan Gursel, Mayda Heegaard, Niels H. H. Hendrix, An Kierulf, Peter Kokubun, Katsutoshi Kosanović, Maja M. Kralj-Iglic, Veronika Krämer-Albers, Eva-Maria Laitinen, Saara Lässer, Cecilia Lener, Thomas Ligeti, Erzsébet Oliveira, Carla Pállinger, Éva Lipps, Georg Llorente, Alicia Lötvall, Jan Portillo, Hernando A. del Rigau, Marina Olivan Riera, Mireia Reventós Puigjaner, Jaume |
Keywords: | Vesícules seminals Fisiologia Espai extracel·lular Seminal vesicles Physiology Extracellular space |
Issue Date: | 14-May-2015 |
Publisher: | Taylor & Francis Group |
Abstract: | In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system. |
Note: | Reproducció del document publicat a: https://doi.org/10.3402/jev.v4.27066 |
It is part of: | Journal Of Extracellular Vesicles, 2015, vol. 4, p. 27066 |
URI: | http://hdl.handle.net/2445/169354 |
Related resource: | https://doi.org/10.3402/jev.v4.27066 |
ISSN: | 2001-3078 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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700406.pdf | 3.68 MB | Adobe PDF | View/Open |
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