Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/170325
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gandioso, Albert | - |
dc.contributor.author | El Fakiri, Mohamed | - |
dc.contributor.author | Rovira, Anna | - |
dc.contributor.author | Marchán Sancho, Vicente | - |
dc.date.accessioned | 2020-09-08T13:25:51Z | - |
dc.date.available | 2020-09-08T13:25:51Z | - |
dc.date.issued | 2020-08-07 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | http://hdl.handle.net/2445/170325 | - |
dc.description.abstract | We describe a novel transition metal-free method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using readily available ethyl bromodifluoroacetate as a fluorine source. The formation of N-difluoromethylated pyridines involves a two-step process in which N-alkylation by ethyl bromodifluoroacetate is followed by in situ hydrolysis of the ester and decarboxylation. Besides optimizing the N-difluoromethylation conditions and assessing the influence of steric and electronic effects on the outcome of the reaction, we have synthesized the N-difluoromethylated analogues of two fluorophores and demonstrated that their spectroscopic properties can be improved through replacement of N-CH3 group by N-CF2H. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1039/d0ra06322c | - |
dc.relation.ispartof | RSC Advances, 2020, vol. 10, p. 29829-29834 | - |
dc.relation.uri | https://doi.org/10.1039/d0ra06322c | - |
dc.rights | cc-by (c) López-Corrales, Marta et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Síntesi orgànica | - |
dc.subject.classification | Compostos de metalls de transició | - |
dc.subject.other | Organic synthesis | - |
dc.subject.other | Transition metal compounds | - |
dc.title | A simple method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 703114 | - |
dc.date.updated | 2020-09-08T13:25:51Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
703114.pdf | 531.65 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License