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Title: | Chemical Modification of Microcin J25 Reveals New Insights on the Stereospecific Requirements for Antimicrobial Activity |
Author: | Martín Gómez, Helena Jorba, Marta Albericio Palomera, Fernando Viñas, Miquel Tulla-Puche, Judit |
Keywords: | Pèptids Antibiòtics Peptides Antibiotics |
Issue Date: | 2-Oct-2019 |
Publisher: | Mdpi |
Abstract: | In this study, microcin J25, a potent antimicrobial lasso peptide that acts on Gram-negative bacteria, was subjected to a harsh treatment with a base in order to interrogate its stability and mechanism of action and explore its structure-activity relationship. Despite the high stability reported for this lasso peptide, the chemical treatment led to the detection of a new product. Structural studies revealed that this product retained the lasso topology, but showed no antimicrobial activity due to the epimerization of a key residue for the activity. Further microbiological assays also demonstrated that it showed a high synergistic effect with colistin. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms20205152 |
It is part of: | International Journal Of Molecular Sciences, 2019-10-02, Vol. 20, num. 20, p. 5152 |
URI: | http://hdl.handle.net/2445/170448 |
Related resource: | https://doi.org/10.3390/ijms20205152 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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Martin-GomezH.pdf | 2.22 MB | Adobe PDF | View/Open |
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