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Title: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) - Incidence and Case-Control Programme
Author: Gayer-Anderson, Charlotte
Jongsma, Hannah E.
Di Forti, Marta
Quattrone, Diego
Velthorst, Eva
Haan, Lieuwe de
Selten, Jean Paul
Szöke, Andrei
Llorca, Pierre Michel
Tortelli, Andrea Tortelli
Arango, Celso
Bobes García, Julio
Bernardo Arroyo, Miquel
Sanjuán, Julio
Santos, José Luis
Arrojo, Manuel
Parellada, Mara
Tarricone, Ilaria
Berardi, Domenico
Ruggeri, Mirella
Lasalvia, Antonio
Ferraro, Laura
Cascia, Caterina La
Barbera, Daniele La
Menezes, Paulo Rossi
Del-Ben, Cristina Marta
EU-GEI WP2 Group
Rutten, Bart P.F.
van Os, Jim
Jones, Peter B.
Murray, Robin M.
Kirkbride, James B.
Morgan, Craig
Keywords: Esquizofrènia
Issue Date: 23-Jan-2020
Publisher: Springer Verlag
Abstract: Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identifed 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial afect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions: This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted
Note: Reproducció del document publicat a:
It is part of: Social Psychiatry and Psychiatric Epidemiology, 2020, num. 55, p. 645-657
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ISSN: 0933-7954
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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