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Title: | A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus |
Author: | Farmakis, Dimitrios Agostoni, Piergiuseppe Baholli, Loant Bautin, Andrei Comín Colet, Josep Crespo Leiro, María G. Fedele, Francesco García-Pinilla, Jose Manuel Giannakoulas, George Grigioni, Francesco Gruchala, Marcin Gustafsson, Finn Harjola, Veli-Pekka Hasin, Tal Herpain, Antoine Iliodromitis, Efstathios K. Karason, Kristjan Kivikko, Matti Liaudet, Lucas Ljubas-Mač ek, Jana Marin, Marco Masip, Josep (Masip i Utset) Mebazaa, Alexandre Nikolaou, Maria Ostada, Petr Põder, Pentti Pollesello, Piero Polyzogopoulou, Eftihia Pölzl, Gerhard Tschope, Carsten Varpula, Marjut von Lewinsk, Dirk Vrtovec, Bojan Birhan Yilmaz, Mehmet Zima, Endre Parissis, John |
Keywords: | Insuficiència cardíaca Farmacologia cardiovascular Heart failure Cardiovascular pharmacology |
Issue Date: | 15-Dec-2019 |
Publisher: | Elsevier B.V. |
Abstract: | Inotropes aim at increasing cardiac output by enhancing cardiac contractility. They constitute the third pharmacological pillar in the treatment of patients with decompensated heart failure, the other two being diuretics and vasodilators. Three classes of parenterally administered inotropes are currently indicated for decompensated heart failure, (i) the beta adrenergic agonists, including dopamine and dobutamine and also the catecholamines epinephrine and norepinephrine, (ii) the phosphodiesterase III inhibitor milrinone and (iii) the calcium sensitizer levosimendan. These three families of drugs share some pharmacologic traits, but differ profoundly in many of their pleiotropic effects. Identifying the patients in need of inotropic support and selecting the proper inotrope in each case remain challenging. The present consensus, derived by a panel meeting of experts from 21 countries, aims at addressing this very issue in the setting of both acute and advanced heart failure. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.ijcard.2019.09.005 |
It is part of: | International Journal of Cardiology, 2019, vol. 297, p. 83-90 |
URI: | http://hdl.handle.net/2445/171113 |
Related resource: | https://doi.org/10.1016/j.ijcard.2019.09.005 |
ISSN: | 0167-5273 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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