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Title: Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinacional EU-GEI study
Author: Quattrone, Diego
Di Forti, Marta
Gayer-Anderson, Charlotte
Ferraro, Laura
Jongsma, Hanna E.
Tripoli, Giada
La Cascia, Caterina
La Barbera, Daniele
Tarricone, Ilaria
Berardi, Domenico
Szöke, Andrei
Arango, Celso
Lasalvia, Antonio
Tortelli, Andrea
Llorca, Pierre Michel
de Haan, Lieuwe
Velthorst, Eva
Bobes García, Julio
Bernardo Arroyo, Miquel
Sanjuán, Julio
Arrojo, Manuel
Del-Ben, Cristina Marta
Menezes, Paulo Rossi
Selten, Jean Paul
EU-GEI WP2 Group
Jones, Peter B.
Kirkbride, James B.
Richards, Alexander L.
O'Donovan, Michael C.
Sham, Pak C.
Vassos, Evangelos
Rutten, Bart P.F.
van Os, Jim
Morgan, Craig
Lewis, Cathryn M.
Murray, Robin M.
Reininghaus, Ulrich
Keywords: Psicosi
Pathological psychology
Issue Date: 24-Jul-2019
Publisher: Cambridge University Press
Abstract: Background: The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and associated characteristics of psychopathology at First Episode Psychosis (FEP). Regardless of diagnostic categories, we expected that positive symptoms occurred more frequently in ethnic minority groups and in more densely populated environments, and that negative symptoms were associated with indices of neurodevelopmental impairment. Method: This study included 2182 FEP individuals recruited across six countries, as part of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Symptom ratings were analysed using multidimensional item response modelling in Mplus to estimate five theory-based models of psychosis. We used multiple regression models to examine demographic and context factors associated with symptom dimensions. Results: A bifactor model, composed of one general factor and five specific dimensions of positive, negative, disorganization, manic and depressive symptoms, best-represented associations among ratings of psychotic symptoms. Positive symptoms were more common in ethnic minority groups. Urbanicity was associated with a higher score on the general factor. Men presented with more negative and less depressive symptoms than women. Early age-at-first-contact with psychiatric services was associated with higher scores on negative, disorganized, and manic symptom dimensions. Conclusions: Our results suggest that the bifactor model of psychopathology holds across diagnostic categories of non-affective and affective psychosis at FEP, and demographic and context determinants map onto general and specific symptom dimensions. These findings have implications for tailoring symptom-specific treatments and inform research into the mood-psychosis spectrum.
Note: Reproducció del document publicat a:
It is part of: Psychological Medicine, 2019, vol. 49, num. 8, p. 1378-1391
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ISSN: 0033-2917
Appears in Collections:Articles publicats en revistes (Medicina)
Publicacions de projectes de recerca finançats per la UE

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