Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/171134
Title: | Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinacional EU-GEI study |
Author: | Quattrone, Diego Di Forti, Marta Gayer-Anderson, Charlotte Ferraro, Laura Jongsma, Hanna E. Tripoli, Giada La Cascia, Caterina La Barbera, Daniele Tarricone, Ilaria Berardi, Domenico Szöke, Andrei Arango, Celso Lasalvia, Antonio Tortelli, Andrea Llorca, Pierre Michel de Haan, Lieuwe Velthorst, Eva Bobes García, Julio Bernardo Arroyo, Miquel Sanjuán, Julio Arrojo, Manuel Del-Ben, Cristina Marta Menezes, Paulo Rossi Selten, Jean Paul EU-GEI WP2 Group Jones, Peter B. Kirkbride, James B. Richards, Alexander L. O'Donovan, Michael C. Sham, Pak C. Vassos, Evangelos Rutten, Bart P.F. van Os, Jim Morgan, Craig Lewis, Cathryn M. Murray, Robin M. Reininghaus, Ulrich |
Keywords: | Psicosi Esquizofrènia Psicopatologia Psychoses Schizophrenia Pathological psychology |
Issue Date: | 24-Jul-2019 |
Publisher: | Cambridge University Press |
Abstract: | Background: The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and associated characteristics of psychopathology at First Episode Psychosis (FEP). Regardless of diagnostic categories, we expected that positive symptoms occurred more frequently in ethnic minority groups and in more densely populated environments, and that negative symptoms were associated with indices of neurodevelopmental impairment. Method: This study included 2182 FEP individuals recruited across six countries, as part of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Symptom ratings were analysed using multidimensional item response modelling in Mplus to estimate five theory-based models of psychosis. We used multiple regression models to examine demographic and context factors associated with symptom dimensions. Results: A bifactor model, composed of one general factor and five specific dimensions of positive, negative, disorganization, manic and depressive symptoms, best-represented associations among ratings of psychotic symptoms. Positive symptoms were more common in ethnic minority groups. Urbanicity was associated with a higher score on the general factor. Men presented with more negative and less depressive symptoms than women. Early age-at-first-contact with psychiatric services was associated with higher scores on negative, disorganized, and manic symptom dimensions. Conclusions: Our results suggest that the bifactor model of psychopathology holds across diagnostic categories of non-affective and affective psychosis at FEP, and demographic and context determinants map onto general and specific symptom dimensions. These findings have implications for tailoring symptom-specific treatments and inform research into the mood-psychosis spectrum. |
Note: | Reproducció del document publicat a: https://doi.org/10.1017/S0033291718002131 |
It is part of: | Psychological Medicine, 2019, vol. 49, num. 8, p. 1378-1391 |
URI: | http://hdl.handle.net/2445/171134 |
Related resource: | https://doi.org/10.1017/S0033291718002131 |
ISSN: | 0033-2917 |
Appears in Collections: | Articles publicats en revistes (Medicina) Publicacions de projectes de recerca finançats per la UE |
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