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Title: What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity
Author: Steward, Trevor
Juaneda Seguí, Asier
Mestre-Bach, Gemma
Martínez Zalacaín, Ignacio
Vilarrasa, Nuria
Jiménez-Murcia, Susana
Fernández Formoso, Jose A.
Veciana de las Heras, Misericordia
Custal, Nuria
Virgili, Núria
Lopez Urdiales, Rafael
García Ruiz de Gordejuela, Amador
Menchón Magriñá, José Manuel
Soriano Mas, Carles
Fernández Aranda, Fernando
Keywords: Obesitat
Imatges per ressonància magnètica
Escorça frontal
Magnetic resonance imaging
Prefrontal cortex
Issue Date: 2019
Publisher: MDPI
Abstract: Altered activity in decision-making neural circuitry may underlie the maladaptive food choices found in obesity. Here, we aimed to identify the brain regions purportedly underpinning risk-taking behavior in individuals with obesity. Twenty-three adult women with obesity and twenty-three healthy weight controls completed the Risky Gains Task during functional magnetic resonance imaging (fMRI). This task allows participants to choose between a safe option for a small, guaranteed monetary reward and risky options with larger rewards. fMRI analyses comparing losing trials to winning trials found that participants with obesity presented decreased activity in the left anterior insula in comparison to controls (p < 0.05, AlphaSim corrected). Moreover, left insula activation during losses vs. wins was negatively correlated with UPPS-P questionnaire sensation seeking scores. During safe vs. risky trials following a loss, the control group exhibited increased activation in the ventromedial prefrontal cortex (vmPFC) (p < 0.05, AlphaSim corrected) in comparison to the OB group. Moreover, vmPFC response in the obesity group during post-loss trials was negatively correlated with risky choices on the task overall. As a whole, our findings support that diminished tuning of the insula towards interoceptive signals may lead to a lack of input to the vmPFC when weighing the costs and benefits of risky choices.
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It is part of: Journal of Clinical Medicine, 2019, vol. 8, num. 10, p. 1551
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ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Publicacions de projectes de recerca finançats per la UE

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