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Title: Mechanosensitive single molecule dynamics of myosin II
Author: Colomer Rosell, Mariona
Director/Tutor: Venturini, Valeria
Wieser, Stefan
Casademunt i Viader, Jaume
Keywords: Miosina
Dinàmica molecular
Treballs de fi de grau
Molecular dynamics
Bachelor's theses
Issue Date: Jun-2020
Abstract: In this project we have characterised the dynamics of single myosin II molecules in stem cells under mechanical stress combining high spatial and time resolution microscopy with image analysis and simulations. We show that in the bleb, intensity of myosin spots increases as they assemble into bipolar thick filaments. In comparison with the myosin II under the nucleus, in the bleb they undergo a super dffusive motion which could drive the bleb contraction. We have analysed their spatial distribution using DBSCAN clustering analysis and we have performed Cytosim simulations to study the myosin II dynamics in the retraction bleb. This analysis sets the framework and the computational pipeline for further experiments.
Note: Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2020, Tutors: Valeria Venturini , Stefan Wieser i Jaume Casademunt
Appears in Collections:Treballs Finals de Grau (TFG) - Física

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