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Title: | Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study |
Author: | Baumeister, Sebastian E. Schlesinger, Sabrina Aleksandrova, Krasimira Jochem, Carmen Jenab, Mazda Gunter, Marc J. Overvad, Kim Tjønneland, Anne Boutron-Ruault, Marie-Christine Carbonnel, Franck Fournier, Agnès Kühn, Tilman Kaaks, Rudolf Pischon, Tobias Boeing, Heiner Trichopoulou, Antonia Bamia, Christina Vecchia, Carlo La Masala, Giovanna Panico, Salvatore Fasanelli, Francesca Tumino, Rosario Grioni, Sara Bueno de Mesquita, H. Bas Vermeulen, Roel May, Anne M. Borch, Kristin B. Oyeyemi, Sunday O. Ardanaz, Eva Rodríguez Barranco, Miguel Chirlaque, María Dolores Félez Nóbrega, Mireia Sonestedt, Emily Ohlsson, Bodil Hemmingsson, Oskar Werner, Mårten Pérez Cornago, Aurora Ferrari, Pietro Stepien, Magdalena Freisling, Heinz Tsilidis, Konstantinos K. Ward, Heather Riboli, Elio Weiderpass, Elisabete Leitzmann, Michael F. |
Keywords: | Càncer de fetge Obesitat Diabetis Liver cancer Obesity Diabetes |
Issue Date: | 1-May-2019 |
Publisher: | Elsevier |
Abstract: | Background & Aims: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. Weexamined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection). Results: In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38-0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting >2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33-0.76). Estimates were similar in sensitivity analyses for confounding. Total and vigorous physical activity were unrelated to IHBC and NGBC. In mediation analysis, waist circumference explained about 40% and body mass index 30% of the overall association of total physical activity and HCC. Conclusions: These findings suggest an inverse association between physical activity and risk of HCC, which is potentially mediated by obesity. Lay summary: In a pan-European study of 467,336 men and women, we found that physical activity is associated with a reduced risk of developing liver cancers over the next decade. This risk was independent of other liver cancer risk factors, and did not vary by age, gender, smoking status, body weight, and alcohol consumption. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.jhep.2018.12.014 |
It is part of: | Journal of Hepatology, 2019, vol. 70, num. 5, p. 885-892 |
URI: | https://hdl.handle.net/2445/171513 |
Related resource: | https://doi.org/10.1016/j.jhep.2018.12.014 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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