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Title: Antibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer
Author: Butt, Julia A.
Fernandez de Larrea, Nerea
Tjalsma, Harold
Roelofs, Rian
Kato, Ikuko
Martín Sánchez, Vicente
Pérez Gómez, Beatriz
Moreno Aguado, Víctor
Dierssen Sotos, Trinidad
Castilla, Jesús
Fernández Tardón, Guillermo
Amiano, Pilar
Salas, Dolores
Alguacil, Juan
Jiménez Moleón, José Juan
Huerta Castaño, José María
Sanjosé Llongueras, Silvia de
Campo, Rosa del
Kogevinas, Manolis
Pollán, Marina
Pawlita, Michael
Waterboer, Tim
Boleij, Annemarie
Aragonès Sanz, Núria
Keywords: Càncer colorectal
Colorectal cancer
Issue Date: 26-Jul-2019
Publisher: Nature Publishing Group
Abstract: Antibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to bacterial flagellin C (FliC), a measure potentially related to this impairment, with CRC and the CRC-specific interaction with antibodies to SGG proteins. Antibodies to FliC and SGG pilus proteins Gallo2178 and Gallo2179 were measured in two independent studies, a combined study from Nijmegen and Detroit (93 CRC cases, 74 controls) and a replication data set including 576 cases and 576 controls from the Spanish multicenter multicase-control study (MCC-Spain). Logistic regression was applied to assess whether antibodies to FliC were associated with CRC and modified the association of antibodies to SGG proteins with CRC. Antibodies to FliC were associated with those to SGG Gallo2178 among CRC cases, resulting in an interaction in the association of antibodies to Gallo2178 with CRC (p = 0.007). This association was only present among individuals with high antibody responses to FliC (OR: 2.42, 95% CI: 1.45-4.06). In conclusion, our findings suggest that colorectal tumorigenesis could be accompanied by an impaired integrity of the epithelium that could result in associated increased antibody responses to bacterial proteins.
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It is part of: Scientific Reports, 2019, vol. 9, p. 10847
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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