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http://hdl.handle.net/2445/171571
Title: | Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts |
Author: | Fusté, Noel P. Guasch, M. Guillen, P. Anerillas, C. Cemeli, T. Pedraza, N. Ferrezuelo, F. Encinas, M. Moralejo, M. Garí, Eloi |
Keywords: | Polisacàrids Fibroblasts Polysaccharides Fibroblasts |
Issue Date: | 15-Apr-2019 |
Publisher: | Elsevier Science Ltd. |
Abstract: | β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. Unexpectedly, we have observed that this compound promoted a short-transitory proliferation arrest at 24 h after its addition on the medium. We have determined that this transitory arrest was dependent on the cell-cycle regulator protein Retinoblastoma. Moreover, dermal fibroblasts increase their migration capacities at 24 h after barley β-glucan addition. Also, we have described that barley β-glucan strongly reduced the ability of fibroblasts to attach and to spread on cell plates. Our data indicates that barley β-glucan signal induces an early response in HDF cells favoring migration versus proliferation. This feature is consistent with our observation that the topical addition of our barley β-glucan in vivo accelerates the wound closure in mouse skin. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.carbpol.2019.01.090 |
It is part of: | Carbohydrate Polymers, 2019, vol. 210, p. 389-398 |
URI: | http://hdl.handle.net/2445/171571 |
Related resource: | https://doi.org/10.1016/j.carbpol.2019.01.090 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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FusteNP.pdf | 2.08 MB | Adobe PDF | View/Open |
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