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http://hdl.handle.net/2445/171596
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DC Field | Value | Language |
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dc.contributor.author | Olivé i Plana, Montserrat | - |
dc.contributor.author | Engvall, Martin | - |
dc.contributor.author | Ravenscroft, Gianina | - |
dc.contributor.author | Cabrera Serrano, Macarena | - |
dc.contributor.author | Jiao, Hong | - |
dc.contributor.author | Bortolotti, Carlo Augusto | - |
dc.contributor.author | Pignataro, Marcello | - |
dc.contributor.author | Lambrughi, Matteo | - |
dc.contributor.author | Jiang, Haibo | - |
dc.contributor.author | Forrest, Alistair R. R. | - |
dc.contributor.author | Benseny Cases, Núria | - |
dc.contributor.author | Hofbauer, Stefan | - |
dc.contributor.author | Obinger, Christian | - |
dc.contributor.author | Battistuzzi, Gianantonio | - |
dc.contributor.author | Bellei, Marzia | - |
dc.contributor.author | Borsari, Marco | - |
dc.contributor.author | Di Rocco, Giulia | - |
dc.contributor.author | Viola, Helena M. | - |
dc.contributor.author | Hoo, Livia C. | - |
dc.contributor.author | Cladera, Josep | - |
dc.contributor.author | Lagerstedt Robinson, Kristina | - |
dc.contributor.author | Xiang, Fengqing | - |
dc.contributor.author | Wredenberg, Anna | - |
dc.contributor.author | Miralles, Francesc | - |
dc.contributor.author | Baiges, Juan José | - |
dc.contributor.author | Malfatti, Edoardo | - |
dc.contributor.author | Romero, Norma B. | - |
dc.contributor.author | Streichenberger, Nathalie | - |
dc.contributor.author | Via, Christophe | - |
dc.contributor.author | Claeys, Kristl G. | - |
dc.contributor.author | Straathof, Chiara S.M | - |
dc.contributor.author | Goris, An | - |
dc.contributor.author | Freyer, Christoph | - |
dc.contributor.author | Lammens, Martin | - |
dc.contributor.author | Bassez, Guillaume | - |
dc.contributor.author | Kere, Juha | - |
dc.contributor.author | Clemente, Paula | - |
dc.contributor.author | Sejersen, Thomas | - |
dc.contributor.author | Udd, Bjarne | - |
dc.contributor.author | Vidal, Noemí | - |
dc.contributor.author | Ferrer, Isidro (Ferrer Abizanda) | - |
dc.contributor.author | Edstrom, Lars | - |
dc.contributor.author | Wedell, Anna | - |
dc.contributor.author | Laing, Nigel G. | - |
dc.date.accessioned | 2020-10-28T10:13:58Z | - |
dc.date.available | 2020-10-28T10:13:58Z | - |
dc.date.issued | 2019-01-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/171596 | - |
dc.description.abstract | Myoglobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocytes and oxidative skeletal myofibers. Myoglobin binds O-2, facilitates its intracellular transport and serves as a controller of nitric oxide and reactive oxygen species. Here, we identify a recurrent c.292C>T ( p.His98Tyr) substitution in MB in fourteen members of six European families suffering from an autosomal dominant progressive myopathy with highly characteristic sarcoplasmic inclusions in skeletal and cardiac muscle. Myoglobinopathy manifests in adulthood with proximal and axial weakness that progresses to involve distal muscles and causes respiratory and cardiac failure. Biochemical characterization reveals that the mutant myoglobin has altered O-2 binding, exhibits a faster heme dissociation rate and has a lower reduction potential compared to wild-type myoglobin. Preliminary studies show that mutant myoglobin may result in elevated superoxide levels at the cellular level. These data define a recognizable muscle disease associated with MB mutation. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-019-09111-2 | - |
dc.relation.ispartof | Nature Communications, 2019-01-01, Vol. 10, num. 1396 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-019-09111-2 | - |
dc.rights | cc by (c) Olivé i Plana, Montserrat et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Malalties musculars | - |
dc.subject.classification | Mutació (Biologia) | - |
dc.subject.other | Muscular Diseases | - |
dc.subject.other | Mutation (Biology) | - |
dc.title | Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-10-26T09:24:48Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30918256 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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OliveM.pdf | 2.7 MB | Adobe PDF | View/Open |
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