Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/171618
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Duran, I. | - |
dc.contributor.author | Lambea, Julio | - |
dc.contributor.author | Maroto, P. | - |
dc.contributor.author | González Larriba, José Luis | - |
dc.contributor.author | Flores, Luis | - |
dc.contributor.author | Granados Principal, S. | - |
dc.contributor.author | Graupera i Garcia-Milà, Mariona | - |
dc.contributor.author | Sáez, B. | - |
dc.contributor.author | Vivancos, A. | - |
dc.contributor.author | Casanovas i Casanovas, Oriol | - |
dc.date.accessioned | 2020-10-30T08:21:07Z | - |
dc.date.available | 2020-10-30T08:21:07Z | - |
dc.date.issued | 2016-11-15 | - |
dc.identifier.uri | http://hdl.handle.net/2445/171618 | - |
dc.description.abstract | Renal cell carcinoma (RCC) is a complex disease characterized by mutations in several genes. Loss of function of the von Hippel-Lindau (VHL) is a very common finding in RCC and leads to up-regulation of hypoxia-inducible factor (HIF)-responsive genes accountable for angiogenesis and cell growth, such as platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF). Binding of these proteins to tyrosine kinase receptors (TKR) on endothelial cells promotes angiogenesis. Promotion of angiogenesis is in part due to the activation of the phosphatidylinositol-3-kinase (PI3K)/AKT/mechanistic target of rapamycin (mTOR) pathway. Inhibition of this pathway decreases protein translation and inhibits both angiogenesis and tumour cell proliferation. Although tyrosine kinase inhibitors (TKIs) stand as the main first-line treatment option for advanced RCC, eventually all patients will become resistant to TKIs. Resistance can be overcome by using second-line treatments with different mechanisms of action, such as inhibitors of mTOR, c-MET, programmed death 1 (PD-1) receptor, or the combination of an mTOR inhibitor (mTORi) with a TKI. In this article, we briefly review current evidence regarding mechanisms of resistance in RCC and treatment strategies to overcome resistance with a special focus on the PI3K/AKT/mTOR pathway. | - |
dc.format.extent | 50 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1007/s11523-016-0463-4 | - |
dc.relation.ispartof | Targeted Oncology, 2016, vol. 12, issue. 1, p. 19-35 | - |
dc.relation.uri | https://doi.org/10.1007/s11523-016-0463-4 | - |
dc.rights | (c) Springer Science and Business Media LLC, 2016 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de ronyó | - |
dc.subject.classification | Teràpia genètica | - |
dc.subject.other | Renal cancer | - |
dc.subject.other | Gene therapy | - |
dc.title | Resistance to Targeted Therapies in Renal Cancer: The Importance of Changing the Mechanism of Action | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2020-10-29T14:35:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
CHANGING Molecular Review_FINAL Clean.pdf | 640.14 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.