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Title: Association of selenoprotein and selenium pathway gnotypes with risk of colorectal cancer and interaction with selenium status
Author: Fedirko, Veronika
Jenab, Mazda
Méplan, Catherine
Jones, Jeb S.
Zhu, Wanzhe
Schomburg, Lutz
Siddiq, Afshan
Hybsier, Sandra
Overvad, Kim
Tjønneland, Anne
Omichessan, Hanane
Perduca, Vittorio
Boutron-Ruault, Marie-Christine
Kühn, Tilman
Katzke, Verena
Aleksandrova, Krasimira
Trichopoulou, Antonia
Karakatsani, Anna
Kotanidou, Anastasia
Tumino, Rosario
Panico, Salvatore
Masala, Giovanna
Agnoli, Claudia
Naccarati, Alessio
Bueno de Mesquita, H. Bas
Vermeulen, Roel C.H.
Weiderpass, Elisabete
Skeie, Guri
Nøst, Therese Haugdahl
Luján Barroso, Leila
Quirós, J. Ramón
Huerta Castaño, José María
Rodríguez Barranco, Miguel
Barricarte, Aurelio
Gylling, Björn
Harlid, Sophia
Bradbury, Kathryn E.
Wareham, Nick
Khaw, Kay-Tee
Gunter, Marc
Keywords: Seleni
Càncer colorectal
Epidemiologia genètica
Colorectal cancer
Genetic epidemiology
Issue Date: 25-Apr-2019
Publisher: MDPI
Abstract: Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P < 0.1). SNPs in Wingless/Integrated (Wnt) and Transforming growth factor (TGF) beta-signaling genes (FRZB, SMAD3, SMAD7) from pathways affected by Se intake were also associated with CRC risk after multiple testing adjustments. Interactions with Se status (using existing serum Se and Selenoprotein P data) were tested at the SNP, gene, and pathway levels. Pathway analyses using the modified Adaptive Rank Truncated Product method suggested that genes and gene x Se status interactions in antioxidant, apoptosis, and TGF-beta signaling pathways may be associated with CRC risk. This study suggests that SNPs in the Se pathway alone or in combination with suboptimal Se status may contribute to CRC development.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2019, vol. 11, num. 4, p. 935
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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