Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/171677
Title: | Association of selenoprotein and selenium pathway gnotypes with risk of colorectal cancer and interaction with selenium status |
Author: | Fedirko, Veronika Jenab, Mazda Méplan, Catherine Jones, Jeb S. Zhu, Wanzhe Schomburg, Lutz Siddiq, Afshan Hybsier, Sandra Overvad, Kim Tjønneland, Anne Omichessan, Hanane Perduca, Vittorio Boutron-Ruault, Marie-Christine Kühn, Tilman Katzke, Verena Aleksandrova, Krasimira Trichopoulou, Antonia Karakatsani, Anna Kotanidou, Anastasia Tumino, Rosario Panico, Salvatore Masala, Giovanna Agnoli, Claudia Naccarati, Alessio Bueno de Mesquita, H. Bas Vermeulen, Roel C.H. Weiderpass, Elisabete Skeie, Guri Nøst, Therese Haugdahl Luján Barroso, Leila Quirós, J. Ramón Huerta Castaño, José María Rodríguez Barranco, Miguel Barricarte, Aurelio Gylling, Björn Harlid, Sophia Bradbury, Kathryn E. Wareham, Nick Khaw, Kay-Tee Gunter, Marc |
Keywords: | Seleni Genètica Càncer colorectal Epidemiologia genètica Selenium Genetics Colorectal cancer Genetic epidemiology |
Issue Date: | 25-Apr-2019 |
Publisher: | MDPI |
Abstract: | Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengate assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P < 0.1). SNPs in Wingless/Integrated (Wnt) and Transforming growth factor (TGF) beta-signaling genes (FRZB, SMAD3, SMAD7) from pathways affected by Se intake were also associated with CRC risk after multiple testing adjustments. Interactions with Se status (using existing serum Se and Selenoprotein P data) were tested at the SNP, gene, and pathway levels. Pathway analyses using the modified Adaptive Rank Truncated Product method suggested that genes and gene x Se status interactions in antioxidant, apoptosis, and TGF-beta signaling pathways may be associated with CRC risk. This study suggests that SNPs in the Se pathway alone or in combination with suboptimal Se status may contribute to CRC development. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/nu11040935 |
It is part of: | Nutrients, 2019, vol. 11, num. 4, p. 935 |
URI: | http://hdl.handle.net/2445/171677 |
Related resource: | https://doi.org/10.3390/nu11040935 |
ISSN: | 2072-6643 |
Appears in Collections: | Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
690021.pdf | 316.56 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License