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http://hdl.handle.net/2445/171688
Title: | Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort |
Author: | Gasull, Magda Pumarega, José Kiviranta, Hannu Rantakokko, Panu Raaschou-Nielsen, Ole Bergdahl, Ingvar A. Sandanger, Torkjel Manning Goñi, Fernándo Cirera, Lluís Donat Vargas, Carolina Alguacil, Juan Iglesias, Mar Tjønneland, Anne Overvad, Kim Mancini, Francesca Romana Boutron-Ruault, Marie-Christine Severi, Gianluca Johnson, Theron Kuhn, Tilman Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Palli, Domenico Pala, Valeria Tumino, Rosario Naccarati, Alessio Panico, Salvatore Verschuren, Monique Vermeulen, Roel Rylander, Charlotta Nost, Therese Rodríguez Barranco, Miguel Molinuevo, Amaia Chirlaque, María Dolores Ardanaz, Eva Sund, Malin Key, Tim Ye, Weimin Jenab, Mazda Michaud, Dominique Matullo, Giuseppe Canzian, Federico Kaaks, Rudolf Nieters, Alexandra Nothlings, Ute Jeurnink, Suzanne Chajès, Véronique Matejcic, Marco Gunter, Marc Aune, Dagfinn Riboli, Elio Agudo, Antonio González, Carlos Alberto Weiderpass, Elisabete Bueno de Mesquita, H. Bas Duell, Eric J. Vineis, Paolo Porta, Miquel, 1957- |
Keywords: | Càncer de pàncrees Marcadors bioquímics Contaminants persistents Pancreas cancer Biochemical markers Persistent pollutants |
Issue Date: | 1-Feb-2019 |
Publisher: | Academic Press Inc Elsevier Science |
Abstract: | Background: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. Objectives: First, to summarize the main design features of a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles. Methods: Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models. Results: There were differences among countries in subjects' characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last followup, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, country, and smoking. We detected and quantified 16 of the 22 POPs in more than 90% of individuals. All 22 POPs were detected in some participants, and the smallest number of POPs detected in one person was 15 (median, 19) with few differences by country. The highest concentrations were found for p,p'-DDE, PCBs 153 and 180 (median concentration: 3371, 1023, and 810 pg/mL, respectively). We assessed the possible occurrence of disease progression bias (DPB) in eight situations defined by lipid and POP measurements, on one hand, and by four factors: interval from blood draw to index date, tumour subsite, tumour stage, and grade of differentiation, on the other. In seven of the eight situations results supported the absence of DPB. Conclusions: The coexistence of differences across study centres in some design features and participant characteristics is of relevance to other multicentre studies. Relationships among subjects' characteristics and among such characteristics and design features may play important roles in the forthcoming analyses on the association between plasma concentrations of POPs and pancreatic cancer risk. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.envres.2018.11.027 |
It is part of: | Environmental Research, 2019-02-01, Vol. 169, P. 417-433 |
URI: | http://hdl.handle.net/2445/171688 |
Related resource: | https://doi.org/10.1016/j.envres.2018.11.027 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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