Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/171698
Title: | Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort |
Author: | Sanikini, Harinakshi Muller, David C. Sophiea, Marisa Rinaldi, Sabina Agudo, Antonio Duell, Eric J. Weiderpass, Elisabete Overvad, Kim Tjønneland, Anne Halkjær, Jytte Boutron-Ruault, Marie-Christine Carbonnel, Franck Cervenka, Iris Boeing, Heiner Kaaks, Rudolf Kühn, Tilman Trichopoulou, Antonia Martimianaki, Georgia Karakatsani, Anna Pala, Valeria Palli, Domenico Mattiello, Amalia Tumino, Rosario Sacerdote, Carlotta Skeie, Guri Rylander, Charlotta Chirlaque, María Dolores Sánchez, María José Ardanaz, Eva Regnér, Sara Stocks, Tanja Bueno de Mesquita, H. Bas Vermeulen, Roel C. H. Aune, Dagfinn Tong, Tammy Y. N. Kliemann, Nathalie Murphy, Neil Chadeau-Hyam, Marc Gunter, Marc J. Cross, Amanda J. |
Keywords: | Càncer Nutrició Cancer Nutrition |
Issue Date: | 21-May-2019 |
Publisher: | John Wiley & Sons, Inc. |
Abstract: | Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5–25 kg/m2: HR = 1.94, 95% CI: 1.25–3.03) and women (HR = 2.66, 95% CI: 1.15–6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99–6.06 for WHR >0.96 vs. <0.91; HR = 2.67, 95% CI: 1.52–4.72 for WC >98 vs. <90 cm) and women (HR = 4.40, 95% CI: 1.35–14.33 for WHR >0.82 vs. <0.76; HR = 5.67, 95% CI: 1.76–18.26 for WC >84 vs. <74 cm). WHR was also positively associated with GC in women, and WC was positively associated with GC in men. Inverse associations were observed between parity and EA (HR = 0.38, 95% CI: 0.14–0.99; >2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32–0.91; >26 vs. <22 years); whereas bilateral ovariectomy was positively associated with GNC (HR = 1.87, 95% CI: 1.04–3.36). These findings support a role for hormonal pathways in upper gastrointestinal cancers. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/ijc.32386 |
It is part of: | International Journal of Cancer, 2019, vol. 146, num. 4, p. 929-942 |
URI: | https://hdl.handle.net/2445/171698 |
Related resource: | https://doi.org/10.1002/ijc.32386 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
3. Sanikini et al 2020.pdf | 339.2 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.