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http://hdl.handle.net/2445/171705
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DC Field | Value | Language |
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dc.contributor.author | Mena Cervigón, Marisa | - |
dc.contributor.author | Frias Gomez, Jon | - |
dc.contributor.author | Taberna, Miren | - |
dc.contributor.author | Quirós, Beatriz | - |
dc.contributor.author | Marquez, Sandra | - |
dc.contributor.author | Clavero, Omar | - |
dc.contributor.author | Baena, A. | - |
dc.contributor.author | Lloveras Rubio, Betlem | - |
dc.contributor.author | Alejo, Maria | - |
dc.contributor.author | León, X. | - |
dc.contributor.author | García, J. | - |
dc.contributor.author | Mesía Nin, Ricard | - |
dc.contributor.author | Bermejo, O. | - |
dc.contributor.author | Bonfill, T. | - |
dc.contributor.author | Aguilà, Anton | - |
dc.contributor.author | Guix, M. | - |
dc.contributor.author | Hijano, R. | - |
dc.contributor.author | Pavón Ribas, Miquel Àngel | - |
dc.contributor.author | Torres, M. | - |
dc.contributor.author | Tous, Sara | - |
dc.contributor.author | Clèries Soler, Ramon | - |
dc.contributor.author | Alemany i Vilches, Laia | - |
dc.date.accessioned | 2020-11-03T17:47:09Z | - |
dc.date.available | 2020-11-03T17:47:09Z | - |
dc.date.issued | 2020-08-06 | - |
dc.identifier.uri | http://hdl.handle.net/2445/171705 | - |
dc.description.abstract | The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern Europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal cancer from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16INK4a immunohistochemistry. Data were collected from medical records. Factors associated with HPV positivity and time trends were evaluated with multivariable Bayesian models. The adjusted prevalence of HPV-related cases in 864 patients with a valid HPV-DNA result was 9.7%, with HPV-DNA/p16INK4a double positivity being considered. HPV-related oropharyngeal cancer was likely to occur in non-smokers and non-drinkers, to be located in the tonsil or diagnosed at advanced stages. Time-trend analysis showed an increasing risk of HPV-related oropharyngeal cancer in the most recent periods (5-year period increase of 30%). This increase was highest and with a clear increasing trend only in the most recent years (2012–2016). The prevalence of HPV-related oropharyngeal cancer started to sharply increase in the most recent years in our setting, as occurred two decades ago in areas where most oropharyngeal cancer cases are currently HPV-related. Our results provide a comprehensive assessment of the epidemiological landscape of HPV-related oropharyngeal cancer in a region of southern Europe. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Research | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-70118-7 | - |
dc.relation.ispartof | Scientific Reports, 2020, vol. 10 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-020-70118-7 | - |
dc.rights | cc by (c) Mena Cervigón et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Papil·lomavirus | - |
dc.subject.classification | Càncer de coll | - |
dc.subject.classification | Epidemiologia | - |
dc.subject.other | Papillomaviruses | - |
dc.subject.other | Neck cancer | - |
dc.subject.other | Epidemiology | - |
dc.title | Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 708850 | - |
dc.date.updated | 2020-11-03T17:07:07Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32764593 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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