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Title: Immune Cell Associations with Cancer Risk
Author: Palomero, Luis
Galván Femenía, Ivan
Cid, Rafael de
Espín, Roderic
Barnes, Daniel R.
Blommaert, Eline
Gil Gil, Miguel
Falo, Catalina
Stradella, Agostina
Ouchi, Dan
Roso Llorach, Albert
Violan, Concepció
Peña Chilet, María
Dopazo, Joaquín
Extremera, Ana I.
Garcia Valero, Mar
Herranz, Carmen
Mateo González, Francesca
Mereu, Elisabetta
Beesley, Jonathan
Chenevix-Trench, Georgia
Roux, Cecilia
Mak, Tak
Brunet, Joan
Hakem, Razq
Gorrini, Chiara
Antoniou, Antonis C.
Lázaro García, Conxi
Pujana Genestar, M. Ángel
Keywords: Càncer de mama
Cèl·lules immunocompetents
Breast cancer
Immunocompetent cells
Issue Date: 24-Jul-2020
Publisher: Cell Press
Abstract: Proper immune system function hinders cancer development, but little is known about whether genetic variants linked to cancer risk alter immune cells. Here, we report 57 cancer risk loci associated with differences in immune and/or stromal cell contents in the corresponding tissue. Predicted target genes show expression and regulatory associations with immune features. Polygenic risk scores also reveal associations with immune and/or stromal cell contents, and breast cancer scores show consistent results in normal and tumor tissue. SH2B3 links peripheral alterations of several immune cell types to the risk of this malignancy. Pleiotropic SH2B3 variants are associated with breast cancer risk in BRCA1/2 mutation carriers. A retrospective case-cohort study indicates a positive association between blood counts of basophils, leukocytes, and monocytes and age at breast cancer diagnosis. These findings broaden our knowledge of the role of the immune system in cancer and highlight promising prevention strategies for individuals at high risk.
Note: Reproducció del document publicat a:
It is part of: iScience, 2020, vol. 23, num. 7, p. 101296
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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