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Title: | Genetically Determined Height and Risk of Non-hodgkin Lymphoma |
Author: | Moore, Amy Kane, Eleanor Wang, Zhaoming Panagiotou, Orestis A. Teras, Lauren R. Monnereau, Alain Doo, Nicole Wong Machiela, Mitchell J. Skibola, Christine F. Slager, Susan L. Salles, Gilles Camp, Nicola J. Bracci, Paige M. Nieters, Alexandra Vermeulen, Roel C. H. Vijai, Joseph Smedby, Karin E. Zhang, Yawei Vajdic, Claire M. Cozen, Wendy Spinelli, John J. Hjalgrim, Henrik Giles, Graham G. Link, Brian K. Clavel, Jacqueline Arslan, Alan A. Purdue, Mark P. Tinker, Lesley F. Albanes, Demetrius Ferri, Giovanni M. Habermann, Thomas M. Adami, Hans-Olov Becker, Nikolaus Benavente, Yolanda Bisanzi, Simonetta Boffetta, Paolo Brennan, Paul Brooks-Wilson, Angela R. Canzian, Federico Conde, Lucía Cox, David G. Curtin, Karen Foretova, Lenka Gapstur, Susan M. Ghesquières, Hervé Glenn, Martha Glimelius, Bengt Jackson, Rebecca D. Lan, Qing Liebow, Mark Maynadié, Marc McKay, James D. Melbye, Mads Miligi, Lucia Milne, Roger L. Molina, Thierry J. Morton, Lindsay M. North, Kari E. Offit, Kenneth Padoan, Marina Patel, Alpa V. Piro, Sara Ravichandran, Vignesh Riboli, Elio Sanjosé Llongueras, Silvia de Severson, Richard K. Southey, Melissa C. Staines, Anthony Stewart, Carolyn Travis, Ruth C. Weiderpass, Elisabete Weinstein, Stephanie Zheng, Tongzhang Chanock, Stephen J. Chatterjee, Nilanjan Rothman, Nathaniel Birmann, Brenda M. Cerhan, James R. Berndt, Sonja I. |
Keywords: | Malaltia de Hodgkin Leucèmia limfocítica crònica Genètica Hodgkin's disease Chronic lymphocytic leukemia Genetics |
Issue Date: | 28-Jan-2020 |
Publisher: | Frontiers Media Sa |
Abstract: | Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fonc.2019.01539 |
It is part of: | Frontiers in Oncology, 2020, vol. 9 |
URI: | http://hdl.handle.net/2445/171751 |
Related resource: | https://doi.org/10.3389/fonc.2019.01539 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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