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Title: Occupational exposure to ionizing radiation and risk of lymphoma subtypes: results of the Epilymph European case-control study
Author: Satta, Giannina
Loi, Matteo
Becker, Nikolaus
Benavente, Yolanda
Sanjosé Llongueras, Silvia de
Foretova, Lenka
Staines, Anthony
Maynadié, Marc
Nieters, Alexandra
Meloni, Federico
Pilia, Ilaria
Campagna, Marcello
Pau, Marco
Zablotska, Lydia B.
Cocco, Pierluigi
Keywords: Limfomes
Radiació ionitzant
Ionizing radiation
Issue Date: 25-Apr-2020
Publisher: BioMed Central
Abstract: Background: Evidence linking risk of lymphoma and B-cell lymphoma subtypes to ionizing radiation is inconclusive, particularly at low exposure levels. Methods: We investigated risk of lymphoma (all subtypes), B-cell lymphomas, and its major subtypes, associated with low-level occupational exposure to ionizing radiation, in 2346 lymphoma cases and 2463 controls, who participated in the multicenter EpiLymph case-control study. We developed a job-exposure matrix to estimate exposure to ionizing radiation, distinguishing between internal and external radiation, and we applied it to the lifetime occupational history of study subjects, We calculated the Odds Ratio (OR) and its 95% confidence interval (95% CI) for lymphoma (all subtypes combined), B-cell lymphoma, and its major subtypes using unconditional, polytomous logistic regression adjusting for age, gender, and education. Results: We did not observe an association between exposure metrics of external and internal radiation and risk of lymphoma (all subtypes), nor with B-cell lymphoma, or its major subtypes, at the levels regularly experienced in occupational settings. An elevated risk of diffuse large B cell lymphoma was observed among the most likely exposed study subjects with relatively higher exposure intensity, which would be worth further investigation. Conclusions: Further investigation is warranted on risk of B cell lymphoma subtypes associated with low-level occupational exposure to external ionizing radiation, and to clarify whether lymphoma should be included among the cancer outcomes related to ionizing radiation.
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It is part of: Environmental Health, 2020, vol. 19,num. 43
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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