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Title: Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Author: Papadimitriou, Nikos
Dimou, Niki
Tsilidis, Konstantinos K.
Banbury, Barbara L.
Martin, Richard M.
Lewis, Sarah J.
Kazmi, Nabila
Robinson, Timothy M.
Albanes, Demetrius
Aleksandrova, Krasimira
Berndt, Sonja I.
Bishop, D. Timothy
Brenner, Hermann
Buchanan, Daniel D.
Bueno de Mesquita, H. Bas
Campbell, Peter T.
Castellví Bel, Sergi
Chan, Andrew T.
Chang-Claude, Jenny
Ellingjord-Dale, Merete
Figueiredo, Jane C.
Gallinger, Steven
Giles, Graham G.
Giovannucci, Edward
Gruber, Stephen B.
Gsur, Andrea
Hampe, Jochen
Hampel, Heather
Harlid, Sophia
Harrison, Tabitha A.
Hoffmeister, Michael
Hopper, John L.
Hsu, Li
Huerta Castaño, José María
Huyghe, Jeroen R.
Jenkins, Mark A.
Keku, Temitope O.
Kühn, Tilman
Vecchia, Carlo La
Marchand, Loïc Le
Li, Christopher I.
Li, Li
Lindblom, Annika
Lindor, Noralane M.
Lynch, Brigid
Markowitz, Sanford D.
Masala, Giovanna
May, Anne M.
Milne, Roger L.
Monninkhof, Evelyn M.
Moreno, Lorena
Moreno Aguado, Víctor
Newcomb, Polly A.
Offit, Kenneth
Perduca, Vittorio
Pharoah, Paul D. P.
Platz, Elizabeth A.
Potter, John D.
Rennert, Gad
Riboli, Elio
Sánchez, María José
Schmit, Stephanie L.
Schoen, Robert E.
Severi, Gianluca
Sieri, Sabina
Slattery, Martha L.
Song, Mingyang
Tangen, Catherine M.
Thibodeau, Stephen N.
Travis, Ruth C.
Trichopoulou, Antonia
Ulrich, Cornelia M.
van Duijnhoven, Franzel J. B.
Van Guelpen, Bethany
Vodicka, Pavel
White, Emily
Wolk, Alicja
Woods, Michael O.
Wu, Anna H.
Peters, Ulrike
Gunter, Marc J.
Murphy, Neil
Keywords: Càncer de mama
Càncer colorectal
Condició física
Breast cancer
Colorectal cancer
Physical fitness
Issue Date: 30-Jan-2020
Publisher: Nature Publishing Group
Abstract: Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value=0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value=0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.
Note: Reproducció del document publicat a:
It is part of: Nature Communications, 2020, vol. 11
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Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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