Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/171823
Title: | Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia |
Author: | Llorens Torres, Franc Hermann, Peter Villar Piqué, Anna Diaz Lucena, Daniela Nägga, Katarina Hansson, Oskar Santana, Isabel Schmitz, Matthias Schmidt, Christian Varges, Daniela Goebel, Stefan Dumurgier, Julien Zetterberg, Henrik Blennow, Kaj Paquet, Claire Baldeiras, Inês Ferrer, Isidro (Ferrer Abizanda) Zerr, Inga |
Keywords: | Demència Marcadors bioquímics Dementia Biochemical markers |
Issue Date: | 30-Jan-2020 |
Publisher: | Nature Publishing Group |
Abstract: | The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimer's disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high percentage of macrophages linked to subacute infarcts, reactive astrocytes, and damaged blood vessels in multi-infarct dementia when compared to AD. We conclude that CSF LCN2 is a promising candidate biochemical marker in the differential diagnosis of VaD and neurodegenerative dementias. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-020-14373-2 |
It is part of: | Nature Communications, 2020, vol. 11, p. 619 |
URI: | http://hdl.handle.net/2445/171823 |
Related resource: | https://doi.org/10.1038/s41467-020-14373-2 |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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