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Title: Violent aggression predicted by multiple pre-adult environmental hits
Author: Mitjans Niubó, Marina
Seidel, Jan
Begemann, Martin
Bockhop, Fabian
Moya Higueras, Jorge
Bansal, Vikas
Wesolowski, Janina
Seelbach, Anna
Ibáñez, Manuel I.
Kovacevic, Fatka
Duvar, Oguzhan
Fañanás Saura, Lourdes
Wolf, Hannah U.
Ortet, Generós
Zwanzger, Peter
Klein, Verena
Lange, Ina
Tänzer, Andreas
Dudeck, Manuela
Penke, Lars
Tebartz van Elst, Ludger
Bittner, Robert A.
Schmidmeier, Richard
Freese, Roland
Müller-Isberner, Rüdiger
Wiltfang, Jens
Bliesener, Thomas
Bonn, Stefan
Poustka, Luise
Müller, Jürgen L.
Arias Sampériz, Bárbara
Ehrenreich, Hannelore
Keywords: Impacte ambiental
Malalties mentals
Environmental impact
Mental illness
Issue Date: 24-May-2018
Publisher: Nature Publishing Group
Abstract: Early exposure to negative environmental impact shapes individual behavior and potentially contributes to any mental disease. We reported previously that accumulated environmental risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed that high-risk subjects had >5 times greater probability of forensic hospitalization. In line with longstanding sociological theories, we hypothesized that risk accumulation before adulthood induces violent aggression and criminal conduct, independent of mental illness. We determined in 6 independent cohorts (4 schizophrenia and 2 general population samples) pre-adult risk exposure, comprising urbanicity, migration, physical and sexual abuse as primary, and cannabis or alcohol as secondary hits. All single hits by themselves were marginally associated with higher violent aggression. Most strikingly, however, their accumulation strongly predicted violent aggression (odds ratio 10.5). An epigenome-wide association scan to detect differential methylation of blood-derived DNA of selected extreme group individuals yielded overall negative results. Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as 'umbrella mediator' of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention.
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It is part of: Molecular Psychiatry, 2018, vol. 24, num. 10, p. 1549-1564
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ISSN: 1359-4184
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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