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Title: | Violent aggression predicted by multiple pre-adult environmental hits |
Author: | Mitjans Niubó, Marina Seidel, Jan Begemann, Martin Bockhop, Fabian Moya Higueras, Jorge Bansal, Vikas Wesolowski, Janina Seelbach, Anna Ibáñez, Manuel I. Kovacevic, Fatka Duvar, Oguzhan Fañanás Saura, Lourdes Wolf, Hannah U. Ortet, Generós Zwanzger, Peter Klein, Verena Lange, Ina Tänzer, Andreas Dudeck, Manuela Penke, Lars Tebartz van Elst, Ludger Bittner, Robert A. Schmidmeier, Richard Freese, Roland Müller-Isberner, Rüdiger Wiltfang, Jens Bliesener, Thomas Bonn, Stefan Poustka, Luise Müller, Jürgen L. Arias Sampériz, Bárbara Ehrenreich, Hannelore |
Keywords: | Impacte ambiental Malalties mentals Esquizofrènia Environmental impact Mental illness Schizophrenia |
Issue Date: | 24-May-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Early exposure to negative environmental impact shapes individual behavior and potentially contributes to any mental disease. We reported previously that accumulated environmental risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed that high-risk subjects had >5 times greater probability of forensic hospitalization. In line with longstanding sociological theories, we hypothesized that risk accumulation before adulthood induces violent aggression and criminal conduct, independent of mental illness. We determined in 6 independent cohorts (4 schizophrenia and 2 general population samples) pre-adult risk exposure, comprising urbanicity, migration, physical and sexual abuse as primary, and cannabis or alcohol as secondary hits. All single hits by themselves were marginally associated with higher violent aggression. Most strikingly, however, their accumulation strongly predicted violent aggression (odds ratio 10.5). An epigenome-wide association scan to detect differential methylation of blood-derived DNA of selected extreme group individuals yielded overall negative results. Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as 'umbrella mediator' of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41380-018-0043-3 |
It is part of: | Molecular Psychiatry, 2018, vol. 24, num. 10, p. 1549-1564 |
URI: | http://hdl.handle.net/2445/171856 |
Related resource: | https://doi.org/10.1038/s41380-018-0043-3 |
ISSN: | 1359-4184 |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
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