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Title: SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism
Author: Benson, Sam
Fernandez, Antonio
Barth, Nicole D.
de Moliner, Fabio
Horrocks, Mathew H.
Herrington, C. Simon
Abad, José Luis
Delgado Cirilo, Antonio
Kelly, Lisa
Chang, Ziyuan
Feng, Yi
Nishiure, Miyako
Hori, Yuichiro
Kikuchi, Kazuya
Vendrell, Marc
Keywords: Metabòlits
Cèl·lules canceroses
Motilitat cel·lular
Cancer cells
Cell motility
Issue Date: 28-Mar-2019
Publisher: Wiley-VCH
Abstract: The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small‐sized multi‐colored fluorophores for real‐time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.
Note: Reproducció del document publicat a:
It is part of: Angewandte Chemie-International Edition, 2019, vol. 58, num. 21, p. 6911-6915
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ISSN: 1433-7851
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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