Por favor, use este identificador para citar o enlazar este documento:
https://hdl.handle.net/2445/171943
Título: | Long-term effects in bone mineral density after different bariatric procedures in patients with type 2 diabetes: outcomes of a randomized clinical trial |
Autor: | Guerrero Pérez, Fernando Casajoana, Anna Gómez Vaquero, Carmen Virgili, Núria López Urdiales, Rafael Hernández Montoliu, Laura Pujol Gebelli, Jordi Osorio, Javier Prats, Anna Pujol Gebelli, Jordi Pérez Maraver, Manuel Fernández Veledo, Sonia Vendrell, Joan Vilarrasa, Nuria |
Materia: | Densitat mineral òssia Cirurgia de l'obesitat Bone density Obesity surgery |
Fecha de publicación: | 1-jun-2020 |
Publicado por: | MDPI |
Resumen: | There is scant evidence of the long-term effects of bariatric surgery on bone mineral density (BMD). We compared BMD changes in patients with severe obesity and type 2 diabetes (T2D) 5 years after randomization to metabolic gastric bypass (mRYGB), sleeve gastrectomy (SG) and greater curvature plication (GCP). We studied the influence of first year gastrointestinal hormone changes on final bone outcomes. Forty-five patients, averaging 49.4 (7.8) years old and body mass index (BMI) 39.4 (1.9) kg/m(2), were included. BMD at lumbar spine (LS) was lower after mRYGB compared to SG and GCP: 0.89 [0.82;0.94] vs. 1.04 [0.91;1.16] vs. 0.99 [0.89;1.12],p= 0.020. A higher percentage of LS osteopenia was present after mRYGB 78.6% vs. 33.3% vs. 50.0%, respectively. BMD reduction was greater in T2D remitters vs. non-remitters. Weight at fifth year predicted BMD changes at the femoral neck (FN) (adjustedR(2): 0.3218;p= 0.002), and type of surgery (mRYGB) and menopause predicted BMD changes at LS (adjustedR(2): 0.2507;p< 0.015). In conclusion, mRYGB produces higher deleterious effects on bone at LS compared to SG and GCP in the long-term. Women in menopause undergoing mRYGB are at highest risk of bone deterioration. Gastrointestinal hormone changes after surgery do not play a major role in BMD outcomes. |
Nota: | Reproducció del document publicat a: https://doi.org/10.3390/jcm9061830 |
Es parte de: | Journal of Clinical Medicine, 2020, vol. 9, num. 6 |
URI: | https://hdl.handle.net/2445/171943 |
Recurso relacionado: | https://doi.org/10.3390/jcm9061830 |
Aparece en las colecciones: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Archivos de este documento:
Archivo | Descripción | Dimensiones | Formato | |
---|---|---|---|---|
Guerrero-PerezF.pdf | 792.26 kB | Adobe PDF | Mostrar/Abrir |
Este documento está sujeto a una
Licencia Creative Commons