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Title: Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study
Author: Peremiquel Trillas, Paula
Benavente, Yolanda
Martín Bustamante, Mayte
Casabonne, Delphine
Pérez Gómez, Beatriz
Gómez Acebo, Inés
Oliete Canela, Anna
Diéguez Rodríguez, Marta
Tusquets, Ignasi
Amiano, Pilar
Mengual Brichs, Lourdes
Ardanaz, Eva
Capelo Álvarez, Rocío
Molina de la Torre, Antonio José
Salas Trejo, Dolores
Fernández Tardón, Guillermo
Lope, Virginia
Jimenez Moleon, Jose J.
Marcos Gragera, Rafael
Dierssen Sotos, Trinidad
Azpiri, Mikel
Muñoz, Montse
Guevara, Marcela
Fernández Villa, Tania
Molina Barceló, Ana
Aragonès Sanz, Núria
Pollán, Marina
Castaño-Vinyals, Gemma
Alguacil, Juan
Kogevinas, Manolis
Sanjosé Llongueras, Silvia de
Costas, Laura
Keywords: Càncer de mama
Càncer de pròstata
Breast cancer
Prostate cancer
Issue Date: 1-Jan-2019
Publisher: Elsevier Ltd.
Abstract: Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Methods: We carried out a population-based case-control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01-1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02-1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00-1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Conclusions: Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies.
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It is part of: Environment International, 2019, vol. 122, p. 389-399
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ISSN: 0160-4120
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Medicina)

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