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Title: Association between norepinephrine levels and abnormal iron status in patients with chronic heart failure: is iron deficiency more than a comorbidity?
Author: Moliner, Pedro
Enjuanes, Cristina
Tajes, Marta
Cainzos Achirica, Miguel
Lupón, Josep
Garay, Alberto
Jiménez Marrero, Santiago
Yun, Sergi
Farré, Núria
Cladellas Capdevila, Mercè
Díez López, Carles
González Costello, José
Comín Colet, Josep
Keywords: Anèmia
Insuficiència cardíaca
Sistema nerviós simpàtic
Heart failure
Sympathetic nervous system
Issue Date: 19-Feb-2019
Publisher: American Heart Association
Abstract: Background-¿Mechanisms underlying iron homeostasis dysregulation in patients with chronic heart failure remain unsettled. In cardiomyocyte models, norepinephrine may lead to intracellular iron depletion, but the potential association between catecholamines (sympathetic activation markers) and iron metabolism biomarkers in chronic heart failure is unknown. Methods and Results-¿In this cross-sectional analysis, we studied the association between plasma norepinephrine levels and serum iron status biomarkers indicating iron storage (ferritin), iron transport (transferrin saturation), and iron demand (soluble transferrin receptor) in a prospective cohort of 742 chronic heart failure patients (mean age, 72 11 years; 56% male). Impaired iron status was defined as ferritin 0.05). Adjusted norepinephrine marginal means were significantly higher in patients with impaired iron status compared with those with normal iron status (528 pg/mL [505-551] versus 482 pg/mL [448-518], respectively; P=0.038). Conclusions-¿In chronic heart failure patients, increased sympathetic activation estimated with norepinephrine levels is associated with impaired iron status and, particularly, dysregulation of biomarkers suggesting impaired iron transport and increased iron demand. Whether the relationship between norepinephrine and iron metabolism is bidirectional and entails causality need to be elucidated in future research. (J Am Heart Assoc. 2019;8:e010887. DOI: 10.1161/JAHA.118.010887.)
Note: Reproducció del document publicat a:
It is part of: Journal of the American Heart Association, 2019, vol. 8, num. 4
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ISSN: 2047-9980
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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