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Title: Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection
Author: Aso Pérez, Ester
Martinsson, Isak
Appelhans, Dietmar
Effenberg, Christiane
Benseny Cases, Núria
Cladera, Josep
Gouras, Gunnar
Ferrer, Isidro (Ferrer Abizanda)
Klementieva, Oxana
Keywords: Trastorns de la memòria
Memory disorders
Issue Date: 1-Apr-2019
Publisher: Future Medicine
Abstract: Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical andbiomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core andmaltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood-brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment.Our data demonstrate that G4HisMal has significantly improved biocompatibility and ability to cross the blood-brain barrier in vivo.Therefore, we suggest that a maltose-histidine shell can be used to improve biocompatibility and ability to cross the blood-brain barrier ofdendrimers. Moreover, G4HisMal demonstrated properties for synapse and memory protection when administered to Alzheimer diseasetransgenic mice. Therefore, G4HisMal can be considered as a promising drug candidate to prevent Alzheimer disease via synapse protection1
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It is part of: Nanomedicine, 2019, vol. 17, p. 198-209
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ISSN: 1743-5889
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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