Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/172007
Títol: Reactive Oxygen Species and Oxidative Stress in the Pathogenesis and Progression of Genetic Diseases of the Connective Tissue
Autor: Egea Guri, Gustavo
Jiménez Altayó, Francesc
Campuzano Uceda, María Victoria
Matèria: Malalties del teixit connectiu
Estrès oxidatiu
Malalties hereditàries
Connective tissues diseases
Oxidative stress
Genetic diseases
Data de publicació: 19-oct-2020
Publicat per: MDPI
Resum: Connective tissue is known to provide structural and functional 'glue' properties to other tissues. It contains cellular and molecular components that are arranged in several dynamic organizations. Connective tissue is the focus of numerous genetic and nongenetic diseases. Genetic diseases of the connective tissue are minority or rare, but no less important than the nongenetic diseases. Here we review the impact of reactive oxygen species (ROS) and oxidative stress on the onset and/or progression of diseases that directly affect connective tissue and have a genetic origin. It is important to consider that ROS and oxidative stress are not synonymous, although they are often closely linked. In a normal range, ROS have a relevant physiological role, whose levels result from a fine balance between ROS producers and ROS scavenge enzymatic systems. However, pathology arises or worsens when such balance is lost, like when ROS production is abnormally and constantly high and/or when ROS scavenge (enzymatic) systems are impaired. These concepts apply to numerous diseases, and connective tissue is no exception. We have organized this review around the two basic structural molecular components of connective tissue: The ground substance and fibers (collagen and elastic fibers).
Nota: Reproducció del document publicat a: https://doi.org/10.3390/antiox9101013
És part de: Antioxidants, 2020, vol. 9, num. 10, p. 1013
URI: https://hdl.handle.net/2445/172007
Recurs relacionat: https://doi.org/10.3390/antiox9101013
ISSN: 2076-3921
Apareix en les col·leccions:Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)

Fitxers d'aquest document:
Fitxer Descripció DimensionsFormat 
704456.pdf579.37 kBAdobe PDFMostrar/Obrir


Aquest document està subjecte a una Llicència Creative Commons Creative Commons