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Title: Muscle imaging in laminopathies: Synthesis study identifies meaningful muscles for follow-up
Author: Gómez Andrés, David
Díaz Manera, Jordi
Alejaldre, Aida
Pulido Valdeolivas, Irene
González Mera, Laura
Olivé i Plana, Montserrat
Vilchez, Juan José
López de Munain, Adolfo
Paradas, Carmen
Muelas, Nuria
Sánchez Montáñez, Ángel
Alonso Jimenez, Alicia
Gómez de la Banda, Marta
Dabaj, Ivana
Bonne, Gisèle
Munell Casadesús, Francina
Carlier, Robert Y.
Quijano Roy, Susana
Keywords: Distròfia muscular
Diagnòstic per la imatge
Muscular dystrophy
Diagnostic imaging
Issue Date: 1-Dec-2018
Publisher: Wiley
Abstract: Introduction: Particular fibroadipose infiltration patterns have been recently described by muscle imaging in congenital and later onset forms of LMNA-related muscular dystrophies (LMNA-RD). Methods: Scores for fibroadipose infiltration of 23 lower limb muscles in 34 patients with LMNA-RD were collected from heat maps of 2 previous studies. Scoring systems were homogenized. Relationships between muscle infiltration and disease duration and age of onset were modeled with random forests. Results: The pattern of infiltration differs according to disease duration but not to age of disease onset. The muscles whose progression best predicts disease duration were semitendinosus, biceps femoris long head, gluteus medius, and semimembranosus. Discussion: In LMNA-RD, our synthetic analysis of lower limb muscle infiltration did not find major differences between forms with different ages of onset but allowed the identification of muscles with characteristic infiltration during disease progression. Monitoring of these specific muscles by quantitative MRI may provide useful imaging biomarkers in LMNA-RD. Muscle Nerve 58:812-817, 2018
Note: Versió postprint del document publicat a:
It is part of: Muscle & Nerve, 2018, vol. 58, num. 6, p. 812-817
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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