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http://hdl.handle.net/2445/172072
Title: | Treatment of multiple myeloma with renal involvement: the nephrologist's view |
Author: | Favà Buch, Alexandre Fulladosa, Xavier Montero Pérez, Núria Draibe, Juliana Torras Ambròs, Joan Gomà, Montse Cruzado, Josep Ma. |
Keywords: | Nefrologia Malalties del ronyó Nephrology Kidney diseases |
Issue Date: | Dec-2018 |
Publisher: | Oxford University Press |
Abstract: | Renal injury is a common complication in multiple myeloma (MM). In fact, as many as 10% of patients with MM develop dialysis-dependent acute kidney injury related to increased free light chain (FLC) production by a plasma cell clone. Myeloma cast nephropathy (MCN) is the most prevalent pathologic diagnosis associated with renal injury, followed by light chain deposition disease and light chain amyloidosis. Several FLC removal techniques have been explored to improve kidney disease in MM but their impact on renal clinical outcomes remains unclear. According to the evidence, high cut-off haemodialysis should be restricted to MM patients on chemotherapy with histological diagnosis of MCN and haemodialysis requirements. From our perspective, more efforts are needed to improve kidney outcomes in patients with MM and renal failure. |
Note: | Reproducció del document publicat a: https://doi.org/10.1093/ckj/sfy065 |
It is part of: | Clinical Kidney Journal, 2018, vol. 11, num. 6, p. 777-785 |
URI: | http://hdl.handle.net/2445/172072 |
Related resource: | https://doi.org/10.1093/ckj/sfy065 |
ISSN: | 2048-8505 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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