Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172121
Title: Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA
Author: Mandelli, Maria Luisa
Welch, Ariane E.
Vilaplana, Eduard
Watson, Christa
Battistella, Giovanni
Brown, Jesse A.
Possin, Katherine L.
Hubbard, Honey I.
Miller, Zachary A.
Henry, Maya L.
Marx, Gabe A.
Santos Santos, Miguel A.
Bajorek, Lynn P.
Fortea Ormaechea, Juan
Boxer, Adam
Rabinovici, Gil D.
Lee, Suzee
Deleon, Jessica
Rosen, Howard J.
Miller, Bruce L.
Seeley, William W.
Gorno Tempini, Maria Luisa
Keywords: Afàsia
Malalties neurodegeneratives
Aphasia
Neurodegenerative Diseases
Issue Date: 1-Nov-2018
Publisher: Elsevier Masson
Abstract: Non-fluent/agrammatic primary progressive aphasia (nfvPPA) is caused by neuro-degeneration within the left fronto-insular speech and language production network (SPN). Graph theory is a branch of mathematics that studies network architecture (topology) by quantifying features based on its elements (nodes and connections). This approach has been recently applied to neuroimaging data to explore the complex architecture of the brain connectome, though few studies have exploited this technique in PPA. Here, we used graph theory on functional MRI resting state data from a group of 20 nfvPPA patients and 20 matched controls to investigate topological changes in response to focal neuro-degeneration. We hypothesized that changes in the network architecture would be specific to the affected SPN in nfvPPA, while preserved in the spared default mode network (DMN). Topological configuration was quantified by hub location and global network metrics. Our findings showed a less efficiently wired and less optimally clustered SPN, while no changes were detected in the DMN. The SPN in the nfvPPA group showed a loss of hubs in the left fronto-parietal-temporal area and new critical nodes in the anterior left inferior-frontal and right frontal regions. Behaviorally, speech production score and rule violation errors correlated with the strength of functional connectivity of the left (lost) and right (new) regions respectively. This study shows that focal neurodegeneration within the SPN in nfvPPA is associated with network-specific topological alterations, with the loss and gain of crucial hubs and decreased global efficiency that were better accounted for through functional rather than structural changes. These findings support the hypothesis of selective network vulnerability in nfvPPA and may offer biomarkers for future behavioral intervention.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.cortex.2018.08.002
It is part of: Cortex, 2018, vol. 108, p. 252-264
URI: http://hdl.handle.net/2445/172121
Related resource: https://doi.org/10.1016/j.cortex.2018.08.002
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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