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http://hdl.handle.net/2445/172137
Title: | Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity |
Author: | Ferreiro Iglesias, Aida Lesseur, Corina McKay, James D. Hung, Rayjean J. Han, Younghun Zong, Xuchen Christiani, David C. Johansson, Mattias Xiao, Xiangjun Li, Yafang Qian, David C. Ji, Xuemei Liu, Geoffrey Caporaso, Neil E. Scelo, Ghislaine Zaridze, David Mukeriya, Anush Kontic, Milica Ognjanovic, Simona Lissowska, Jolanta Szolkowska, Małgorzata Swiatkowska, Beata Janout, Vladimir Holcatova, Ivana Bolca, Ciprian Savic, Milan Ognjanovic, Miodrag Bojesen, Stig E. Wu, Xifeng Albanes, Demetrius Aldrich, Melinda C. Tardón, Adonina Fernandez Somoano, Ana Fernández Tardón, Guillermo Marchand, Loïc Le Rennert, Gadi Chen, Chu Doherty, Jennifer A. Goodman, Gary Bickeböller, Heike Wichmann, H-Erich Risch, Angela Rosenberger, Albert Shen, Hongbing Dai, Juncheng Field, John K. Davies, Michael P. A. Woll, Penella Teare, M. Dawn Kiemeney, Lambertus A. van der Heijden, Erik H. F. M. Yuan, Jian-Min Hong, Yun-Chul Haugen, Aage Zienolddiny, Shanbeh Lam, Stephen Tsao, Ming-Sound Johansson, Mikael Grankvist, Kjell Schabath, Matthew B. Andrew, Angeline S. Duell, Eric J. Melander, Olle Brunnström, Hans Lazarus, Philip Arnold, Susanne M. Slone, Stacey Byun, Jinyoung Kamal, Ahsan Zhu, Dakai Landi, Maria Teresa Amos, Christopher I. Brennan, Paul |
Keywords: | Càncer de pulmó Genètica Lung cancer Genetics |
Issue Date: | 25-Jan-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-05890-2 |
It is part of: | Nature Communications, 2018, vol. 9 |
URI: | http://hdl.handle.net/2445/172137 |
Related resource: | https://doi.org/10.1038/s41467-018-05890-2 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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