Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172162
Title: Transformation of COUPY fluorophores into a novel class of visible light-cleavable photolabile protecting groups
Author: López-Corrales, Marta
Rovira, Anna
Gandioso, Albert
Bosch Marimon, Manel
Nonell, Santi
Marchán Sancho, Vicente
Keywords: Cumarines
Mitocondris
Coumarins
Mitochondria
Issue Date: 12-Jun-2020
Publisher: Wiley-VCH
Abstract: Although photolabile protecting groups (PPGs) have found widespread applications in several fields of chemistry, biology and materials science, there is a growing interest in expanding the photochemical toolbox to overcome some of the limitations of classical caging groups. In this work, the synthesis of a new class of visible-light-sensitive PPGs based on low-molecular weight COUPY fluorophores with several attractive properties, including long-wavelength absorption, is reported. Besides being stable to spontaneous hydrolysis in the dark, COUPY-based PPGs can be efficiently photoactivated with yellow (560 nm) and red light (620 nm) under physicological-like conditions, thereby offering the possibility of unmasking functional groups from COUPY photocages under irradiation conditions in which other PPGs remain stable. Additionally, COUPY photocages exhibit excellent cellular uptake and accumulate selectively in mitochondria, opening the door to delivering caged analogues of biologically active compounds into this organelle
Note: Versió postprint del document publicat a: https://doi.org/10.1002/chem.202002314
It is part of: Chemistry-A European Journal, 2020, vol. 26
URI: http://hdl.handle.net/2445/172162
Related resource: https://doi.org/10.1002/chem.202002314
ISSN: 0947-6539
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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