Title: | Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk |
Author: | Ji, Xuemei Bossé, Yohan Landi, Maria Teresa Gui, Jiang Xiao, Xiangjun Qian, David Joubert, Philippe Lamontagne, Maxime Li, Yafang Gorlov, Ivan Biasi, Mariella de Janout, Vladimir Kontic, Milica Lissowska, Jolanta Scelo, Ghislaine Swiatkowska, Beata Johansson, M Zaridze, David Bakke, Per Skaug, Vidar Zienolddiny, Shanbeh Johansson, Mattias Butler, Lesley M. Byun, Jinyoung Koh, Woon-Puay Obeidat, Ma'en Gao, Yu-Tang Houlston, Richard McLaughlin, John R. Stevens, Victoria Timens, Wim Hung, Rayjean J. Song, Lei Zhu, Bin Gu, Fangyi Soler Artigas, María Tobin, Martin D. Wain, Louise V. Kamal, Ahsan Zhu, Dakai Tardón, Adonina Tyndale, Rachel F. Wei, Wei-Qi Marchand, Loïc Le Chanock, Stephen J. Brennan, Paul Wu, Xifeng Chen, Chu McKay, James D. Liu, Geoffrey Zong, Xuchen Carreras-Torres, Robert Christiani, David C. Caporaso, Neil E. Rennert, Gad Bojesen, Stig E. Schabath, Matthew B. Ye, Yuanqing Albanes, Demetrius Bickeböller, Heike Aldrich, Melinda C. Bush, William S. Teare, M. Dawn Field, John K. Saliba, Walid Su, Li Kiemeney, Lambertus A. L. M. Philip, Lazarus Haugen, Aage Lam, Stephen Andrew, Angeline S. Wilkens, Lynne Shen, Hongbing Diao, Nancy Hong, Yun-Chul Yuan, Jian-Min Davies, Michael P. A. Bertazzi, Pier Alberto Pesatori, Angela Cecilia Zhang, Ruyang Haiman, Christopher Trichopoulou, Antonia Brhane, Yonathan Leighl, Natasha Johansen, Jakob S. Mellemgaard, Anders Fernández Somoano, Ana Doherty, Jennifer A. Fernández Tardón, Guillermo van der Heijden, Erik H. F. M. Kim, Jin Hee Dai, Juncheng Hu, Zhibin Marcus, Michael W. Manz, Judith Brunnström, Hans Tumino, Rosario Manjer, Jonas Tsao, Ming-Sound Melander, Olle Muller, David C. Overvad, Kim Goodman, Gary E. Mukeriya, Anush Cox, Angela Taylor, Fiona Woll, Penella Brüske, Irene Muley, Thomas R. Orlowski, Tadeusz M. Risch, Angela Arnold, Susanne M. Rosenberger, Albert Grankvist, Kjell Johansson, Mikael Shepherd, Frances Haura, Eric B. Duell, Eric J. Bolca, Ciprian Ognjanovic, Simona Nickle, David C. Holcatova, Ivana |
Keywords: | Càncer de pulmó Factors de risc en les malalties Lung cancer Risk factors in diseases |
Issue Date: | 13-Aug-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-05074-y |
It is part of: | Nature Communications, 2018, vol. 9 |
URI: | https://hdl.handle.net/2445/172224 |
Related resource: | https://doi.org/10.1038/s41467-018-05074-y |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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