Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/172282
Title: | The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland |
Author: | Llobet-Navas, David Rodríguez-Barrueco, Ruth Castro, Verónica Ugalde, Alejandro P. Sumazin, Pavel Jacob-Sendler, Damian Demircan, Berna Castillo Martin, Mireia Putcha, Preeti Marshall, Netonia Villagrasa, Patricia Chan, Joseph Sanchez-Garcia, Félix Pe'er, Dana Rabadán, Raul Iavarone, Antonio Cordon Cardo, Carlos Califano, Andrea López-Otin, Carlos Ezhkova, Elena Silva, Jose M. |
Keywords: | Epiteli Metabolisme Expressió gènica Glàndules mamàries Micro RNAs Genètica Epithelium Metabolism Gene expression Mammary glands MicroRNAs Genetics |
Issue Date: | 1-Apr-2014 |
Publisher: | Cold Spring Harbor Laboratory Press |
Abstract: | The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster miR-424(322)/503 as an important regulator of epithelial involution after pregnancy. Through the generation of a knockout mouse model, we found that regression of the secretory acini of the mammary gland was compromised in the absence of miR-424(322)/503. Mechanistically, we show that miR-424(322)/503 orchestrates cell life and death decisions by targeting BCL-2 and IGF1R (insulin growth factor-1 receptor). Furthermore, we demonstrate that the expression of this microRNA cluster is regulated by TGF-β, a well-characterized regulator of mammary involution. Overall, our data suggest a model in which activation of the TGF-β pathway after weaning induces the transcription of miR-424(322)/503, which in turn down-regulates the expression of key genes. Here, we unveil a previously unknown, multilayered regulation of epithelial tissue remodeling coordinated by the microRNA cluster miR-424(322)/503. |
Note: | Reproducció del document publicat a: https://doi.org/10.1101/gad.237404.114 |
It is part of: | Genes & Development, 2014, vol. 28, num. 7, p. 765-782 |
URI: | https://hdl.handle.net/2445/172282 |
Related resource: | https://doi.org/10.1101/gad.237404.114 |
ISSN: | 0890-9369 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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