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Title: Predictors of oropharyngeal cancer survival in Europe
Author: Anantharaman, Devasena
Billot, A.
Waterboer, T.
Gheit, T.
Abedi-Aekani, Behnoush
Lagiou, Pagona
Lagiou, Areti
Ahrens, Wolfgang
Holcatova, I.
Merletti, Franco
Kjaerheim, K.
Polesel, J.
Simonato, L.
Alemany i Vilches, Laia
Mena Cervigón, Marisa
MacFarlane, Tatiana V.
Znaor, A.
Thomson, P. J.
Robinson, M.
Canova, Cristina
Conway, David I.
Wright, S.
Healy, C. M.
Toner, M. E.
Pawlita, M.
Tommasino, M.
Brennan, Paul
Keywords: Càncer de boca
Oral cancer
Issue Date: 1-Jun-2018
Publisher: Elsevier Science
Abstract: Objectives: HPV16-positive oropharyngeal cancer (OPC) patients experience better outcomes compared to HPV16-negative patients. Currently, strategies for treatment de-escalation are based on HPV status, smoking history and disease stage. However, the appropriate cut-point for smoking and the role of other non-clinical factors in OPC survival remains uncertain. Materials and Methods: We examined factors associated with OPC outcome in 321 patients recruited in a large European multi-center study. Seropositivity for HPV16 E6 was used as a marker of HPV16 positive cancer. Hazard ratios (HR) and confidence intervals (CI) were estimated using Cox proportional models adjusted for potential confounders. Results: Overall 5-year survival following OPC diagnosis was 50%. HPV16-positive OPC cases were at significantly lower risk of death (aHR = 0.51, 95% CI: 0.32-0.80). A significant effect on OPC survival was apparent for female sex (aHR 0.50: 95% CI: 0.29-0.85) and being underweight at diagnosis (aHR: 2.41, 95% CI: 1.38-4.21). A 10 pack year smoking history was not associated with overall survival. Higher stage at diagnosis appeared as the only factor significantly associated with OPC recurrence (aHR: 4.88, 95% CI: 2.12-11.21). Conclusion: This study confirms that HPV16 status is an independent prognostic factor for OPC survival while female sex lowers risk of death and being underweight at diagnosis increases the risk of death. Smoking was not an independent predictor of OPC survival.
Note: Reproducció del document publicat a:
It is part of: Oral Oncology, 2018, vol. 81, p. 89-94
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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