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Title: Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study
Author: Gómez Acebo, Inés
Dierssen Sotos, Trinidad
Pedro, María de
Pérez Gómez, Beatriz
Castaño-Vinyals, Gemma
Fernández Villa, Tania
Palazuelos-Calderón, Camilo
Amiano, Pilar
Etxeberria, Jaione
Benavente, Yolanda
Fernández Tardón, Guillermo
Salcedo Bellido, Inmaculada
Capelo Álvarez, Rocío
Peiró, Rosana
Marcos Gragera, Rafael
Huerta Castaño, José María
Tardón, Adonina
Barricarte, Aurelio
Altzibar, Jone M.
Alonso Molero, Jéssica
Dávila Batista, Verónica
Aragonès Sanz, Núria
Pollán, Marina
Kogevinas, Manolis
Llorca, Javier
Keywords: Aspirina
Factors de risc en les malalties
Malalties cardiovasculars
Malalties del tracte gastrointestinal
Risk factors in diseases
Cardiovascular diseases
Gastrointestinal system diseases
Issue Date: 21-Jan-2018
Publisher: BioMed Central
Abstract: Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history. Methods: Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition, participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factors associated with ever and current NSAID consumption were identified by logistic regression. Results: Women consumed more non-aspirin NSAIDs (38.8% [36.7-41.0]) than men (22.3 [20.5-24.2]), but men consumed more aspirin (11.7% [10.3-13.2]) than women (5.2% [4.3-6.3]). Consumption of non-aspirin NSAIDs decrease with age from 44.2% (39.4-49.1) in younger than 45 to 21.1% (18.3-24.2) in older than 75, but the age-pattern for aspirin usage was the opposite. Aspirin was reported by about 11% patients, as being twice as used in men (11.7%) than in women (5.2%); its consumption increased with age from 1.7% (< 45 years old) to 12.4% (>= 75 years old). Aspirin was strongly associated with the presence of cardiovascular risk factors or established cardiovascular disease, reaching odds ratios of 15.2 (7.4-31.2) in women with acute coronary syndrome, 13.3 (6.2-28.3) in women with strokes and 11.1 (7.8-15.9) in men with acute coronary syndrome. Participants with cardiovascular risk factors or diseases consumed as much non-aspirin NSAID as participants without such conditions. Conclusions: Non-aspirin NSAIDs were more consumed by women and aspirin by men. The age patterns of aspirin and non-aspirin NSAIDs were opposite: the higher the age, the lower the non-aspirin NSAIDs usage and the higher the aspirin consumption. People with cardiovascular risk factors or diseases consumed more aspirin, but they did not decrease their non-aspirin NSAIDs usage.
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It is part of: BMC Public Health, 2018, vol. 18
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Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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