Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/172465
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rozen, Esteban J. | - |
dc.contributor.author | Roewenstrunk, Julia | - |
dc.contributor.author | Barallobre, María José | - |
dc.contributor.author | Di Vona, Chiara | - |
dc.contributor.author | Jung, Carole | - |
dc.contributor.author | Figueiredo, Ana F. | - |
dc.contributor.author | Luna Cornadó, Jeroni | - |
dc.contributor.author | Fillat i Fonts, Cristina | - |
dc.contributor.author | Arbonés de Rafael, Maria Lourdes, 1959- | - |
dc.contributor.author | Graupera i Garcia-Milà, Mariona | - |
dc.contributor.author | Valverde, Miguel A. | - |
dc.contributor.author | Luna, Susana de la | - |
dc.date.accessioned | 2020-12-02T14:25:39Z | - |
dc.date.available | 2020-12-02T14:25:39Z | - |
dc.date.issued | 2018-01-08 | - |
dc.identifier.uri | http://hdl.handle.net/2445/172465 | - |
dc.description.abstract | Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is central to endothelial cell angiogenic responses, and it is activated by stimuli like vascular endothelial growth factor (VEGF) A. NFAT phosphorylation by dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) is thought to be an inactivating event. Contrary to expectations, we show that the DYRK family member DYRK1A positively regulates VEGF-dependent NFAT transcriptional responses in primary endothelial cells. DYRK1A silencing reduces intracellular Ca2+ influx in response to VEGF, which dampens NFAT activation. The effect is exerted at the level of VEGFR2 accumulation leading to impairment in PLC gamma 1 activation. Notably, Dyrk1 alpha heterozygous mice show defects in developmental retinal vascularization. Our data establish a regulatory circuit, DYRK1A/C-a2+/NFAT, to fine-tune endothelial cell proliferation and angiogenesis. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cell Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.celrep.2018.04.008 | - |
dc.relation.ispartof | Cell Reports, 2018, vol. 23, num. 6, Pp 1867-1878 | - |
dc.relation.uri | https://doi.org/10.1016/j.celrep.2018.04.008 | - |
dc.rights | cc-by-nc-nd (c) Rozen et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Angiogènesi | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Neovascularization | - |
dc.subject.other | Cancer | - |
dc.title | DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-12-02T08:16:29Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/675392/EU//Phd | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/317250/EU//VESSEL | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29742440 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
This item is licensed under a
Creative Commons License